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First National Bank
U.S. National Register of Historic Places
Virginia Landmarks Register
First National Bank, June 2010
Location within Virginia Location within the United States
Location	101 S. Jefferson St., Roanoke, Virginia
Coordinates	37°16′20″N 79°56′28″W
Area	0.1 acres (0.040 ha)
Built	1910 (1910)
Architect	John Kevan Peebles
Architectural style	French Renaissance
NRHP reference No.	82004591
VLR No.	128-0040
Significant dates
Added to NRHP	June 14, 1982
Designated VLR	February 16, 1982

First National Bank, also known as People's Federal Building and Liberty Trust Co., is a historic bank and office building located at Roanoke, Virginia. It was built in 1910, and is a seven-story, granite and buff-colored brick building in the French Renaissance style. It features a Roman Ionic columned main entrance and Doric columns in the main banking hall derived from the Temple of Apollo at Delos.

The first director of the bank was Henry S. Trout. In 1926 the bank merged with the National Exchange Bank, and took that name. "When the community opened up, there were a lot of members of the Jewish community who have served on various organizations. For instance, Arthur Taubman was on the board of the First National Exchange Bank, on the board of trustees. When that became Dominion Bank, his son, Nicholas F. Taubman, served on that board of trustees, too."

It was listed on the National Register of Historic Places in 1982.