FKBP7

FKBP7
Identifiers
Aliases	FKBP7, FKBP23, PPIase, FK506 binding protein 7, FKBP prolyl isomerase 7
External IDs	OMIM: 607062; MGI: 1336879; GeneCards: FKBP7
Enzyme activity
Gene location (Human)
Chr.	Chromosome 2 (human)
End	178,478,600 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	76,503,460 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; Achilles tendon; ; left ovary; ; right ovary; ; sperm; ; tendon of biceps brachii; ; smooth muscle tissue; ; canal of the cervix; ; tibia; ; Descending thoracic aorta;
	Top expressed in
	calvaria; ; body of femur; ; lower jaw; ; tooth; ; molar; ; efferent ductule; ; dermis; ; Meckel's cartilage; ; fossa; ; atrioventricular valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; FK506 binding; protein binding; isomerase activity; peptidyl-prolyl cis-trans isomerase activity; metal ion binding;
Cellular component	endoplasmic reticulum lumen; endoplasmic reticulum; cytoplasm;
Biological process	chaperone-mediated protein folding; protein peptidyl-prolyl isomerization;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	51661
	14231
	ENSG00000079150
	ENSMUSG00000002732
	Q9Y680
	O54998
	NM_001135212; NM_016105; NM_181342
	NM_010222; NM_001355079; NM_001355080
	NP_001128684; NP_851939
	NP_034352; NP_001342008; NP_001342009
	Wikidata
View/Edit Human	View/Edit Mouse

FK506 binding protein 7 is a protein that in humans is encoded by the FKBP7 gene.^[5] The gene is also known as FKBP23 and PPIase.^[5] FKBP7 belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. Members of this family exhibit PPIase activity and function as molecular chaperones. The orthologous protein in mouse is located in the endoplasmic reticulum and binds calcium.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000079150 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002732 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 "FK506 binding protein 7". Retrieved 2011-12-06.
↑ Nakamura T, Yabe D, Kanazawa N, Tashiro K, Sasayama S, Honjo T (November 1998). "Molecular cloning, characterization, and chromosomal localization of FKBP23, a novel FK506-binding protein with Ca2+-binding ability". Genomics. 54 (1): 89–98. doi:10.1006/geno.1998.5571. PMID 9806833.

Patterson CE, Gao J, Rooney AP, Davis EC (June 2002). "Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family". Genomics. 79 (6): 881–889. doi:10.1006/geno.2002.6777. PMID 12036304.
Matsuda M, Koide T, Yorihuzi T, Hosokawa N, Nagata K (January 2001). "Molecular cloning of a novel ubiquitin-like protein, UBIN, that binds to ER targeting signal sequences". Biochemical and Biophysical Research Communications. 280 (2): 535–540. Bibcode:2001BBRC..280..535M. doi:10.1006/bbrc.2000.4149. PMID 11162551.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000079150 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002732 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 3 "FK506 binding protein 7". Retrieved 2011-12-06.

[6] Nakamura T, Yabe D, Kanazawa N, Tashiro K, Sasayama S, Honjo T (November 1998). "Molecular cloning, characterization, and chromosomal localization of FKBP23, a novel FK506-binding protein with Ca2+-binding ability". Genomics. 54 (1): 89–98. doi:10.1006/geno.1998.5571. PMID 9806833.

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FKBP7

References

Further reading