// Workers AI · dad joke modeWhat did FKBP6 say to its friend? "You can fold on me.

FKBP6
Identifiers
Aliases	FKBP6, FKBP36, FK506 binding protein 6, FKBP prolyl isomerase 6, FKBP prolyl isomerase family member 6 (inactive)
External IDs	OMIM: 604839; MGI: 2137612; GeneCards: FKBP6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3B7X
Gene location (Human)
Chr.	Chromosome 7 (human)
End	73,358,637 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	135,378,898 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; sperm; ; oocyte; ; testicle; ; gonad; ; secondary oocyte; ; striated muscle tissue; ; skeletal muscle tissue; ; olfactory zone of nasal mucosa;
	Top expressed in
	morula; ; spermatocyte; ; seminiferous tubule; ; Gonadal ridge; ; spermatid; ; blastocyst; ; embryo; ; yolk sac; ; primary oocyte; ; ovary;
	More reference expression data
	n/a
Gene ontology
Molecular function	Hsp90 protein binding; protein binding; peptidyl-prolyl cis-trans isomerase activity; identical protein binding; FK506 binding; isomerase activity;
Cellular component	cytosol; synaptonemal complex; nucleus; chromosome; cytoplasm;
Biological process	peptidyl-proline modification; cell differentiation; gene silencing; protein folding; piRNA metabolic process; spermatogenesis; protein peptidyl-prolyl isomerization; DNA methylation involved in gamete generation; chaperone-mediated protein folding; positive regulation of viral genome replication; meiosis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	8468
	94244
	ENSG00000077800
	ENSMUSG00000040013
	O75344
	Q91XW8
	NM_001135211; NM_001281304; NM_003602; NM_001362789
	NM_001277891; NM_001277892; NM_001277893; NM_033571
	NP_001128683; NP_001268233; NP_003593; NP_001349718
	NP_001264820; NP_001264821; NP_001264822; NP_291049
	Wikidata
View/Edit Human	View/Edit Mouse

FK506 binding protein 6, also known as FKBP6, is a human gene. The encoded protein shows structural homology to FKBP immunophilins, which bind to the immunosuppressants FK506 and rapamycin.

FKBP6 is essential for homologous chromosome pairing in meiosis during spermatogenesis. Targeted inactivation of FKBP6 in mice results in infertile males, but apparently normal females. Rats with spermatogenic failure at meiosis were found to have a deletion in the exon 8 portion of the FKBP6 gene.^[5] Mutations in this gene have been associated with male infertility in humans.^[6]

FKBP6 is deleted in Williams syndrome, however this hemizygous loss of FKBP6 is not associated with infertility.^[7]

FKBP6 contains 3 α-helices and 11 β-sheet strands,^[8] and as a FK506-family protein, has been shown to be a potent immunosuppressant which can assist in the prevention of allograft rejections.^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000077800 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040013 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Crackower MA, Kolas NK, Noguchi J, et al. (2003). "Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis". Science. 300 (5623): 1291–5. Bibcode:2003Sci...300.1291C. doi:10.1126/science.1083022. PMC 2882960. PMID 12764197.
↑ Zhang W, Zhang S, Xiao C, Yang Y, Zhoucun A (2007). "Mutation screening of the FKBP6 gene and its association study with spermatogenic impairment in idiopathic infertile men". Reproduction. 133 (2): 511–6. doi:10.1530/REP-06-0125. PMID 17307919.
↑ Metcalfe K, Simeonov E, Beckett W, Donnai D, Tassabehji M (2005). "Autosomal dominant inheritance of Williams-Beuren syndrome in a father and son with haploinsufficiency for FKBP6". Clin Dysmorphol. 14 (2): 61–5. doi:10.1097/00019605-200504000-00002. PMID 15770126. S2CID 34259195.
↑ PDB: 3B7X; "RCSB Protein Data Bank - Structure Summary for 3B7X - Crystal structure of human FK506-Binding Protein 6". Archived from the original on 2012-10-21. Retrieved 2011-04-04.
↑ Siekierka JJ, Hung SH, Poe M, Lin CS, Sigal NH (October 1989). "A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin". Nature. 341 (6244): 755–7. Bibcode:1989Natur.341..755S. doi:10.1038/341755a0. PMID 2477714. S2CID 4363530.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000077800 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040013 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12764197-5] Crackower MA, Kolas NK, Noguchi J, et al. (2003). "Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis". Science. 300 (5623): 1291–5. Bibcode:2003Sci...300.1291C. doi:10.1126/science.1083022. PMC 2882960. PMID 12764197.

[pmid17307919-6] Zhang W, Zhang S, Xiao C, Yang Y, Zhoucun A (2007). "Mutation screening of the FKBP6 gene and its association study with spermatogenic impairment in idiopathic infertile men". Reproduction. 133 (2): 511–6. doi:10.1530/REP-06-0125. PMID 17307919.

[pmid15770126-7] Metcalfe K, Simeonov E, Beckett W, Donnai D, Tassabehji M (2005). "Autosomal dominant inheritance of Williams-Beuren syndrome in a father and son with haploinsufficiency for FKBP6". Clin Dysmorphol. 14 (2): 61–5. doi:10.1097/00019605-200504000-00002. PMID 15770126. S2CID 34259195.

[urlRCSB_Protein_Data_Bank_-_Structure_Summary_for_3B7X_-_Crystal_structure_of_human_FK506-Binding_Protein_6-8] PDB: 3B7X; "RCSB Protein Data Bank - Structure Summary for 3B7X - Crystal structure of human FK506-Binding Protein 6". Archived from the original on 2012-10-21. Retrieved 2011-04-04.

[pmid2477714-9] Siekierka JJ, Hung SH, Poe M, Lin CS, Sigal NH (October 1989). "A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin". Nature. 341 (6244): 755–7. Bibcode:1989Natur.341..755S. doi:10.1038/341755a0. PMID 2477714. S2CID 4363530.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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// Workers AI · dad joke modeWhat did FKBP6 say to its friend? "You can fold on me.

References