FIBP

FIBP
Identifiers
Aliases	FIBP, FGFIBP-1, FGF1 intracellular binding protein, TROFAS
External IDs	OMIM: 608296; MGI: 1926233; HomoloGene: 3106; GeneCards: FIBP; OMA:FIBP - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.1 Start 65,883,740 bp End 65,888,531 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 A Start 5,510,643 bp End 5,515,079 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium right frontal lobe prefrontal cortex right hemisphere of cerebellum apex of heart ganglionic eminence left testis right testis Brodmann area 9 cingulate gyrus Top expressed in lip ventricular zone choroid plexus of fourth ventricle superior frontal gyrus yolk sac primary visual cortex granulocyte dentate gyrus of hippocampal formation granule cell right kidney neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function fibroblast growth factor binding Cellular component extracellular exosome membrane mitochondrion nucleus endomembrane system nuclear speck Biological process fibroblast growth factor receptor signaling pathway platelet aggregation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9158 58249 Ensembl ENSG00000172500 ENSMUSG00000024911 UniProt O43427 Q9JI19 RefSeq (mRNA) NM_004214 NM_198897 NM_001253832 NM_021438 RefSeq (protein) NP_004205 NP_942600 NP_001240761 NP_067413 Location (UCSC) Chr 11: 65.88 – 65.89 Mb Chr 19: 5.51 – 5.52 Mb PubMed search
Wikidata
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Acidic fibroblast growth factor intracellular-binding protein is a protein that in humans is encoded by the FIBP gene.

Function

Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene.

Interactions

FIBP has been shown to interact with FGF1.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Kolpakova E, Frengen E, Stokke T, Olsnes S (2000). "Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein". Biochem. J. 352 (3): 629–35. doi:10.1042/0264-6021:3520629. PMC 1221498. PMID 11104667.
• Tassi E, Al-Attar A, Aigner A, Swift MR, McDonnell K, Karavanov A, Wellstein A (2001). "Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein". J. Biol. Chem. 276 (43): 40247–53. doi:10.1074/jbc.M104933200. PMID 11509569.
• Skjerpen CS, Nilsen T, Wesche J, Olsnes S (2002). "Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity". EMBO J. 21 (15): 4058–69. doi:10.1093/emboj/cdf402. PMC 126148. PMID 12145206.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.