// Workers AI · dad joke modeWhat did FEZ1 wear? A hat to the top of its gene list.
Fasciculation and elongation protein zeta-1 is a protein that in humans is encoded by the FEZ1 gene.[5][6][7]
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described.[7]
This protein is present in neurons, and it is believed to block the process of infection of these cells by HIV.[8]
Interactions
[edit]FEZ1 has been shown to interact with Protein kinase Mζ,[9] NBR1[10] and DISC1.[11]
References
[edit]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000149557 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032118 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Bloom L, Horvitz HR (May 1997). "The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation". Proceedings of the National Academy of Sciences of the United States of America. 94 (7): 3414–3419. Bibcode:1997PNAS...94.3414B. doi:10.1073/pnas.94.7.3414. PMC 20384. PMID 9096408.
- ↑ Suzuki T, Okada Y, Semba S, Orba Y, Yamanouchi S, Endo S, et al. (June 2005). "Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation". The Journal of Biological Chemistry. 280 (26): 24948–24956. doi:10.1074/jbc.M411499200. PMID 15843383.
- 1 2 "Entrez Gene: FEZ1 fasciculation and elongation protein zeta 1 (zygin I)".
- ↑ Haedicke J, Brown C, Naghavi MH (August 2009). "The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection". Proceedings of the National Academy of Sciences of the United States of America. 106 (33): 14040–14045. Bibcode:2009PNAS..10614040H. doi:10.1073/pnas.0900502106. PMC 2729016. PMID 19667186.
- ↑ Kuroda S, Nakagawa N, Tokunaga C, Tatematsu K, Tanizawa K (February 1999). "Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein". The Journal of Cell Biology. 144 (3): 403–411. doi:10.1083/jcb.144.3.403. PMC 2132904. PMID 9971736.
- ↑ Whitehouse C, Chambers J, Howe K, Cobourne M, Sharpe P, Solomon E (January 2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". European Journal of Biochemistry. 269 (2): 538–545. doi:10.1046/j.0014-2956.2001.02681.x. PMID 11856312.
- ↑ Miyoshi K, Honda A, Baba K, Taniguchi M, Oono K, Fujita T, et al. (July 2003). "Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth". Molecular Psychiatry. 8 (7): 685–694. doi:10.1038/sj.mp.4001352. PMID 12874605.
Further reading
[edit]- Surpili MJ, Delben TM, Kobarg J (2004). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1". Biochemistry. 42 (51): 15369–15376. doi:10.1021/bi034575v. PMID 14690447.
- Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, et al. (September 2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Molecular Cell. 15 (6): 853–865. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
- Okumura F, Hatakeyama S, Matsumoto M, Kamura T, Nakayama KI (December 2004). "Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis". The Journal of Biological Chemistry. 279 (51): 53533–53543. doi:10.1074/jbc.M402916200. PMID 15466860.
- Yamada K, Nakamura K, Minabe Y, Iwayama-Shigeno Y, Takao H, Toyota T, et al. (November 2004). "Association analysis of FEZ1 variants with schizophrenia in Japanese cohorts". Biological Psychiatry. 56 (9): 683–690. doi:10.1016/j.biopsych.2004.08.015. PMID 15522253. S2CID 42525017.
- Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, et al. (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–968. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
- Assmann EM, Alborghetti MR, Camargo ME, Kobarg J (2006). "FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region". The Journal of Biological Chemistry. 281 (15): 9869–9881. doi:10.1074/jbc.M513280200. PMID 16484223.
- Blasius TL, Cai D, Jih GT, Toret CP, Verhey KJ (January 2007). "Two binding partners cooperate to activate the molecular motor Kinesin-1". The Journal of Cell Biology. 176 (1): 11–17. doi:10.1083/jcb.200605099. PMC 2063617. PMID 17200414.
- Koga M, Ishiguro H, Horiuchi Y, Albalushi T, Inada T, Iwata N, et al. (May 2007). "Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population". Neuroscience Letters. 417 (3): 326–329. doi:10.1016/j.neulet.2007.02.055. PMID 17374448. S2CID 33689793.
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