Exportin-2
| CSE1L | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | CSE1L, CAS, CSE1, XPO2, chromosome segregation 1 like | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 601342; MGI: 1339951; GeneCards: CSE1L | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Exportin-2 is a protein that in humans is encoded by the CSE1L gene (previously CAS). It functions an exportin which in the nucleus is bound to RanGTP.
Function
[edit]The Cas family of proteins are a family of proteins that induce cellular apoptosis and cell proliferation.[5] Apoptosis is a specialized sequence of events that a cell can induce for programmed death. Cas is a 2 terminal protein, a N-terminal and a C-terminal, and there is a positive correlation between the presence of CAS and the degree of cellular proliferation. Along with this correlation, in the absence of the CAS protein in a cell, there is an inhibition of apoptosis Along with being an inducer of apoptosis, CAS also plays a role in being a checkpoint for cell cycle.[5] Without the CAS protein, a cell will not be able to go beyond the G2 phase. It is in the nucleus of the cell, where its exportin function comes into play.
See also
[edit]References
[edit]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000124207 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002718 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- 1 2 Jiang MC (October 2016). "CAS (CSE1L) signaling pathway in tumor progression and its potential as a biomarker and target for targeted therapy". Tumour Biology. 37 (10): 13077–13090. doi:10.1007/s13277-016-5301-x. PMID 27596143. S2CID 31420897.
External links
[edit]- Cellular+Apoptosis+Susceptibility+Protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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