// Workers AI · dad joke modeWhat did Exocyst complex component 6B say? I'm bonded to my work.

EXOC6B
Identifiers
Aliases	EXOC6B, SEC15B, SEC15L2, exocyst complex component 6B, SEMDJL3
External IDs	OMIM: 607880; MGI: 1923164; GeneCards: EXOC6B
Gene location (Human)
Chr.	Chromosome 2 (human)
End	72,826,041 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	85,046,495 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; internal globus pallidus; ; corpus callosum; ; sural nerve; ; external globus pallidus; ; pars compacta; ; pars reticulata; ; left ventricle; ; right auricle of heart; ; apex of heart;
	Top expressed in
	otic vesicle; ; gastrula; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; olfactory epithelium; ; superior frontal gyrus; ; central gray substance of midbrain; ; lumbar subsegment of spinal cord; ; hippocampus proper; ; molar;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	exocyst; membrane;
Biological process	exocytosis; vesicle docking involved in exocytosis; protein transport; Golgi to plasma membrane transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	23233
	75914
	ENSG00000144036
	ENSMUSG00000033769
	Q9Y2D4
	A6H5Z3
NM_015189; NM_001321729; NM_001321730; NM_001321731; NM_001321733;
	NM_001321734
	NM_177077
NP_001308658; NP_001308659; NP_001308660; NP_001308662; NP_001308663;
	NP_056004
	NP_796051
	Wikidata
View/Edit Human	View/Edit Mouse

Exocyst complex component 6B is a protein that in humans is encoded by the EXOC6B gene.^[5]

Function

In yeast and rat, Sec15 is part of a multiprotein complex that is required for targeted exocytosis.^[5]

1 2 3 GRCh38: Ensembl release 89: ENSG00000144036 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033769 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: Exocyst complex component 6B".

Brymora A, Valova VA, Larsen MR, Roufogalis BD, Robinson PJ (August 2001). "The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene". The Journal of Biological Chemistry. 276 (32): 29792–7. doi:10.1074/jbc.C100320200. PMID 11406615.
Feng S, Knödler A, Ren J, Zhang J, Zhang X, Hong Y, Huang S, Peränen J, Guo W (May 2012). "A Rab8 guanine nucleotide exchange factor-effector interaction network regulates primary ciliogenesis". The Journal of Biological Chemistry. 287 (19): 15602–9. doi:10.1074/jbc.M111.333245. PMC 3346093. PMID 22433857.
Wen J, Lopes F, Soares G, Farrell SA, Nelson C, Qiao Y, Martell S, Badukke C, Bessa C, Ylstra B, Lewis S, Isoherranen N, Maciel P, Rajcan-Separovic E (July 2013). "Phenotypic and functional consequences of haploinsufficiency of genes from exocyst and retinoic acid pathway due to a recurrent microdeletion of 2p13.2". Orphanet Journal of Rare Diseases. 8: 100. doi:10.1186/1750-1172-8-100. PMC 3710273. PMID 23837398.
Borsani G, Piovani G, Zoppi N, Bertini V, Bini R, Notarangelo L, Barlati S (2008). "Cytogenetic and molecular characterization of a de-novo t(2p;7p) translocation involving TNS3 and EXOC6B genes in a boy with a complex syndromic phenotype". European Journal of Medical Genetics. 51 (4): 292–302. doi:10.1016/j.ejmg.2008.02.006. PMID 18424204.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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