// Workers AI · dad joke modeWhat did Ewingella americana say? "I'm a-maize-d to meet you.
| Ewingella americana | |
|---|---|
Scientific classification  | |
| Domain: | Bacteria |
| Kingdom: | Pseudomonadati |
| Phylum: | Pseudomonadota |
| Class: | Gammaproteobacteria |
| Order: | Enterobacterales |
| Family: | Yersiniaceae |
| Genus: | Ewingella |
| Species: | E. americana |
| Binomial name | |
| Ewingella americana Grimont et al. 1984[1] | |
Ewingella americana is a Gram-negative rod, and the only species in the genus Ewingella. It was first identified and characterized in 1983. Ewingella is in the family Yersiniaceae. The organism is rarely reported as a human pathogen, though it has been isolated from a variety of clinical specimens, including wounds, sputum, urine, stool, blood, synovial fluid,[2] conjunctiva, and peritoneal dialysate.[3] The bacterium is named in honor of William H. Ewing, an American biologist who contributed to modern taxonomy.
Epidemiology
[edit]Respiratory-tract infections following retainment in intensive-care units has been observed in several instances.[citation needed] A case of E. americana causing osteomyelitis and septic arthritis of the shoulder joint in a previous intravenous drug abuser has also been reported.[4] Vascular bypass surgery is a reported risk factor for colonization.[5][6] Debate currently exists as to this organism's predilection for immunocompromised patients.[7]
Pathophysiology and biochemistry
[edit]E. americana is an organism with simple nutritional needs that can survive in water and citrate solution, and preferentially grows at 4 °C. Domestic sources of water, including air conditioning units, ice baths, and wound irrigation systems, have been cited as sources of infection.[8]
Health studies
[edit]In 2025, a study from the Japan Advanced Institute of Science and Technology showed that a single dose of Ewingella americana eliminated colorectal cancer tumors in mice.
The bacteria naturally sought out the low-oxygen environments inside solid tumors, multiplying rapidly inside the cancer site without harming healthy organs, it directly damaged and destroyed tumor cells (cytotoxic effect) but more importantly triggered T cells, B cells, and neutrophils to attack the cancer and establishes long-lasting immune memory to prevent tumor regrowth.[9][10] [11][12]
References
[edit]- ↑ Parte, A.C. "Ewingella". LPSN.
- ↑ Hassan S, Amer S, Mittal C, Sharma R (2012). "Ewingella americana: an emerging true pathogen". Case Reports in Infectious Diseases. 2012 730720. doi:10.1155/2012/730720. PMC 3384899. PMID 22762003.
- ↑ Nam-Hee Ryoo; Jung-Sook Ha; Dong-Seok Jeon; Jae-Ryong Kim; Hyun-Chul Kim. (2005). "A Case of Pneumonia Caused by Ewingella americana in a Patient with Chronic Renal Failure". J Korean Med Sci. 20 (1): 143–5. doi:10.3346/jkms.2005.20.1.143. ISSN 1011-8934. PMC 2808562. PMID 15716620.
- ↑ Hassan S, Amer S, Mittal C, Sharma R (2012). "Ewingella americana: an emerging true pathogen". Case Reports in Infectious Diseases. 2012 730720. doi:10.1155/2012/730720. PMC 3384899. PMID 22762003.
- ↑ Bear, N.; K. P. Klugman; L. Tobiansky & H. J. Koornhof (1986). "Wound colonization by Ewingella americana". J. Clin. Microbiol. 23 (3): 650–651. doi:10.1128/JCM.23.3.650-651.1986. PMC 268717. PMID 3958154.
- ↑ Devreese, K.; G. Claeys & G. Verschraegen (1992). "Septicemia with Ewingella americana". J. Clin. Microbiol. 30 (10): 2746–2747. doi:10.1128/JCM.30.10.2746-2747.1992. PMC 270514. PMID 1400980.
- ↑ Heizmann, W. R.; R. Michel (1991). "Isolation of Ewingella americana from a patient with conjunctivitis". Eur. J. Clin. Microbiol. Infect. Dis. 10 (11): 957–959. doi:10.1007/bf02005452. PMID 1794367. S2CID 8589322.
- ↑ Farmer, J. J. III; B. R. Davis; F. W. Hickman-Brenner; A. Mc-Whorther; G. P. Huntley-Carter; M. A. Asbury; C. Riddle; H. J. Wathern-Grady; C. Elias; G. R. Fanning; A. G. Steigerwalt; C. M. O'Hara; G. K. Morris; P. B. Smith & D. J. Brenner (1985). "Biochemical identification of new species and biogroups of Enterobacteriaceae isolated from clinical specimens". J. Clin. Microbiol. 21 (1): 46–76. doi:10.1128/JCM.21.1.46-76.1985. PMC 271578. PMID 3881471.
- ↑ "Gut Bacteria from Amphibians and Reptiles Achieve Complete Tumor Elimination". JAIST.
- ↑ Thompson, Bronwyn (December 17, 2025). "Frog gut bacterium eliminates cancer tumors in mice with a single dose". Refractor.
- ↑ Farmer, J. J. III; B. R. Davis; F. W. Hickman-Brenner; A. Mc-Whorther; G. P. Huntley-Carter; M. A. Asbury; C. Riddle; H. J. Wathern-Grady; C. Elias; G. R. Fanning; A. G. Steigerwalt; C. M. O'Hara; G. K. Morris; P. B. Smith & D. J. Brenner (1985). "Biochemical identification of new species and biogroups of Enterobacteriaceae isolated from clinical specimens". J. Clin. Microbiol. 21 (1): 46–76. doi:10.1128/JCM.21.1.46-76.1985. PMC 271578. PMID 3881471.
- ↑ Iwata, Seigo; Yamasita, Nagi; Asukabe, Kensuke; Sakari, Matomo; Miyako, Eijiro (10 December 2025). "Discovery and characterization of antitumor gut microbiota from amphibians and reptiles: Ewingella americana as a novel therapeutic agent with dual cytotoxic and immunomodulatory properties". Gut Microbes. 17 (1) 2599562. doi:10.1080/19490976.2025.2599562. PMC 12710904. PMID 41376334.