EXOC6

EXOC6
Identifiers
Aliases	EXOC6, EXOC6A, SEC15, SEC15L, SEC15L1, SEC15L3, Sec15p, exocyst complex component 6
External IDs	OMIM: 609672; MGI: 1351611; HomoloGene: 41305; GeneCards: EXOC6; OMA:EXOC6 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q23.33 Start 92,826,831 bp End 93,059,493 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19 C2|19 32.32 cM Start 37,509,327 bp End 37,672,507 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in deltoid muscle pancreatic epithelial cell vastus lateralis muscle middle temporal gyrus tibialis anterior muscle buccal mucosa cell Skeletal muscle tissue of biceps brachii Skeletal muscle tissue of rectus abdominis islet of Langerhans placenta Top expressed in soleus muscle extraocular muscle digastric muscle sternocleidomastoid muscle temporal muscle intercostal muscle triceps brachii muscle granulocyte thoracic diaphragm Region I of hippocampus proper More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytosol plasma membrane exocyst cytoplasm growth cone cell projection perinuclear region of cytoplasm Flemming body membrane Biological process protein transport vesicle docking involved in exocytosis exocytosis Golgi to plasma membrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54536 107371 Ensembl ENSG00000138190 ENSMUSG00000053799 UniProt Q8TAG9 Q8R313 RefSeq (mRNA) NM_001013848 NM_019053 NM_001319194 NM_001319195 NM_001319200 NM_175353 RefSeq (protein) NP_001013870 NP_001306123 NP_001306124 NP_001306129 NP_061926 n/a Location (UCSC) Chr 10: 92.83 – 93.06 Mb Chr 19: 37.51 – 37.67 Mb PubMed search
Wikidata
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Exocyst complex component 6 is a protein that in humans is encoded by the EXOC6 gene.

Function

The protein encoded by this gene is highly similar to the Saccharomyces cerevisiae SEC15 gene product, which is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. The 5' portion of this gene and two neighboring cytochrome p450 genes are included in a deletion that results in an autosomal dominant form of nonsyndromic optic nerve aplasia (ONA). Alternative splicing and the use of alternative promoters results in multiple transcript variants. A paralogous gene encoding a similar protein is present on chromosome 2.

Further reading

• Zhang XM, Ellis S, Sriratana A, Mitchell CA, Rowe T (October 2004). "Sec15 is an effector for the Rab11 GTPase in mammalian cells". The Journal of Biological Chemistry. 279 (41): 43027–34. doi:10.1074/jbc.M402264200. PMID 15292201.
• Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A (January 2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". American Journal of Human Genetics. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.
• France YE, Boyd C, Coleman J, Novick PJ (March 2006). "The polarity-establishment component Bem1p interacts with the exocyst complex through the Sec15p subunit". Journal of Cell Science. 119 (Pt 5): 876–88. doi:10.1242/jcs.02849. PMID 16478783.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Molecular Medicine. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Guichard A, McGillivray SM, Cruz-Moreno B, van Sorge NM, Nizet V, Bier E (October 2010). "Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst". Nature. 467 (7317): 854–8. Bibcode:2010Natur.467..854G. doi:10.1038/nature09446. PMC 5831355. PMID 20944747.
• Tatonetti NP, Dudley JT, Sagreiya H, Butte AJ, Altman RB (October 2010). "An integrative method for scoring candidate genes from association studies: application to warfarin dosing". BMC Bioinformatics. 11 (Suppl 9): S9. doi:10.1186/1471-2105-11-S9-S9. PMC 2967750. PMID 21044367.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.