// Workers AI · dad joke modeWhat did ELAC1 gene say? I'm a cut above.

ELAC1
Identifiers
Aliases	ELAC1, D29, elaC ribonuclease Z 1
External IDs	OMIM: 608079; MGI: 1890495; HomoloGene: 10272; GeneCards: ELAC1; OMA:ELAC1 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3ZWF
Enzyme activity
Gene location (Human)
Chr.	Chromosome 18 (human)
End	50,988,121 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	73,887,550 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; Achilles tendon; ; gonad; ; right adrenal gland; ; right lobe of thyroid gland; ; body of pancreas; ; left adrenal gland; ; testicle; ; right adrenal cortex; ; left adrenal cortex;
	Top expressed in
	retinal pigment epithelium; ; lacrimal gland; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus; ; ciliary body; ; substantia nigra; ; central gray substance of midbrain; ; median eminence; ; arcuate nucleus; ; lumbar subsegment of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nuclease activity; endonuclease activity; 3'-tRNA processing endoribonuclease activity; hydrolase activity; metal ion binding; endoribonuclease activity, producing 5'-phosphomonoesters;
Cellular component	cytoplasm; cytosol; nucleus;
Biological process	tRNA 3'-trailer cleavage; RNA phosphodiester bond hydrolysis, endonucleolytic; tRNA processing; tRNA 3'-trailer cleavage, endonucleolytic;
	Sources:Amigo / QuickGO
Orthologs
	55520
	114615
	ENSG00000141642
	ENSMUSG00000036941
	Q9H777
	Q8VEB6
	NM_018696
	NM_053255
	NP_061166
	NP_444485
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc phosphodiesterase ELAC protein 1 is an enzyme that in humans is encoded by the ELAC1 gene.^[5]^[6]

Function

The enzyme is a phosphodiesterase.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000141642 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036941 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Takaku H, Minagawa A, Takagi M, Nashimoto M (Apr 2003). "A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease". Nucleic Acids Res. 31 (9): 2272–8. doi:10.1093/nar/gkg337. PMC 154223. PMID 12711671.
↑ "Entrez Gene: ELAC1 elaC homolog 1 (E. coli)".

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yanaihara N, Kohno T, Takakura S, et al. (2001). "Physical and transcriptional map of a 311-kb segment of chromosome 18q21, a candidate lung tumor suppressor locus". Genomics. 72 (2): 169–79. doi:10.1006/geno.2000.6454. PMID 11401430.
Tavtigian SV, Simard J, Teng DH, et al. (2001). "A candidate prostate cancer susceptibility gene at chromosome 17p". Nat. Genet. 27 (2): 172–80. doi:10.1038/84808. PMID 11175785. S2CID 7889550.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000141642 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036941 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12711671-5] Takaku H, Minagawa A, Takagi M, Nashimoto M (Apr 2003). "A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease". Nucleic Acids Res. 31 (9): 2272–8. doi:10.1093/nar/gkg337. PMC 154223. PMID 12711671.

[entrez-6] "Entrez Gene: ELAC1 elaC homolog 1 (E. coli)".

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// Workers AI · dad joke modeWhat did ELAC1 gene say? I'm a cut above.

Function

References

Further reading