Dysosmobacter
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| Dysosmobacter | |
|---|---|
Scientific classification  | |
| Domain: | Bacteria |
| Kingdom: | Bacillati |
| Phylum: | Bacillota |
| Class: | Clostridia |
| Order: | Eubacteriales |
| Family: | Oscillospiraceae |
| Genus: | Dysosmobacter Le Roy et al., 2020 |
| Type species | |
| Dysosmobacter welbionis | |
| Species | |
Dysosmobacter is a genus of strictly anaerobic, non-spore-forming, rod-shaped bacteria in the family Oscillospiraceae, order Eubacteriales. Members of this genus are part of the gut microbiota of humans and other animals and are of interest for their potential health-related properties, particularly their production of short-chain fatty acids such as butyrate.
Taxonomy
[edit]The genus Dysosmobacter was first described in 2020 by Le Roy et al., who isolated the type species, Dysosmobacter welbionis, from the feces of a healthy human subject.[1]
Two additional species have since been validly published:
- Dysosmobacter hominis, isolated from human feces and described in 2021 by Liu et al. as part of a comprehensive culturomics study of the human gut microbiome.[2]
- Dysosmobacter acutus, isolated from monkey feces and described in 2022 by Li et al.[3]
Etymology
[edit]The name Dysosmobacter derives from the Greek "dysosme" meaning "bad smell" and Latin "bacter" meaning "rod", referring to the strong odor produced by the type strain in culture and its rod-shaped morphology.
Morphology and physiology
[edit]Species of Dysosmobacter are:
- Strictly anaerobic
- Non-motile
- Non-spore-forming
- Rod-shaped
- Gram-negative in staining, although phylogenetically related to Gram-positive clades
They are mesophilic and fermentative, producing SCFAs such as butyrate.
Ecology
[edit]Dysosmobacter species have been isolated from human and non-human primate feces. They are detected in healthy individuals and are considered part of the core gut microbiota.
Functional significance
[edit]Dysosmobacter welbionis has been shown to exert health-promoting effects in mouse models, including:
- Prevention of diet-induced obesity
- Improvement of glucose metabolism
- Reduction of adipose tissue inflammation
These effects were not observed with heat-inactivated cells, indicating that live bacteria are necessary for activity.[4]
Species
[edit]As of 2025, the genus Dysosmobacter includes the following validly published species:
- Dysosmobacter welbionis Le Roy et al. 2020
- Dysosmobacter hominis Liu et al. 2021
- Dysosmobacter acutus Li et al. 2022
See also
[edit]References
[edit]- ↑ Le Roy, T.; Van der Smissen, P.; Paquot, A.; Delzenne, N.; Muccioli, G.G.; Collet, J.F.; Cani, P.D. (September 2020). "Dysosmobacter welbionis gen. nov., sp. nov., isolated from human faeces and emended description of the genus Oscillibacter". International Journal of Systematic and Evolutionary Microbiology. 70 (9): 4851–4858. doi:10.1099/ijsem.0.003547. hdl:2078.1/226713. PMID 31232680.
- ↑ Liu, C.; Du, M.X.; Abuduaini, R.; Yu, H.Y.; Li, D.H.; Wang, Y.J.; Zhou, N.; Jiang, M.Z.; Niu, P.X.; Han, S.S.; Chen, H.H.; Shi, W.Y.; Wu, L.; Xin, Y.H.; Ma, J.; Zhou, Y.; Jiang, C.Y.; Liu, H.W.; Liu, S.J. (May 21, 2021). "Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank". Microbiome. 9 (1): 119. doi:10.1186/s40168-021-01064-3. PMC 8140505. PMID 34020714.
- Liu, C.; Du, M. X.; Abuduaini, R.; Yu, H. Y.; Li, D. H.; Wang, Y. J.; Zhou, N.; Jiang, M. Z.; Niu, P. X.; Han, S. S.; Chen, H. H.; Shi, W. Y.; Wu, L.; Xin, Y. H.; Ma, J.; Zhou, Y.; Jiang, C. Y.; Liu, H. W.; Liu, S. J. (October 3, 2022). "Erratum: Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank". Microbiome. 10 (1): 163. doi:10.1186/s40168-022-01370-4. PMC 9528141. PMID 36192813.
- ↑ Li, D.H.; Abuduaini, R.; Du, M.X.; Wang, Y.J.; Chen, H.H.; Zhou, N.; Zhu, H.Z.; Lu, Y.; Yu, P.J.; Yang, Y.P.; Jiang, C.Y.; Sun, Q.; Liu, C.; Liu, S.J. (March 2022). "Alkaliphilus flagellatus sp. nov., Butyricicoccus intestinisimiae sp. nov., Clostridium mobile sp. nov., Clostridium simiarum sp. nov., Dysosmobacter acutus sp. nov., Paenibacillus brevis sp. nov., Peptoniphilus ovalis sp. nov. and Tissierella simiarum sp. nov., isolated from monkey faeces". International Journal of Systematic and Evolutionary Microbiology. 72 (3): 005276. doi:10.1099/ijsem.0.005276. PMC 9558573. PMID 35258450.
- ↑ Le Roy, T.; Moens de Hase, E.; Van Hul, M.; Paquot, A.; Pelicaen, R.; Régnier, M.; Depommier, C.; Druart, C.; Everard, A.; Maiter, D.; Delzenne, N.M.; Bindels, L.B.; de Barsy, M.; Loumaye, A.; Hermans, M.P.; Thissen, J.P.; Vieira-Silva, S.; Falony, G.; Raes, J.; Muccioli, G.G.; Cani, P.D. (March 2022). "Dysosmobacter welbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice". Gut. 71 (3): 534–543. doi:10.1136/gutjnl-2020-323778. PMC 8862106. PMID 34108237.