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Draft:Hsueh-Chia Chang

From Wikipedia, the free encyclopedia

Hsueh-Chia Chang
Hsueh-Chia Chang Portrait
Hsueh-Chia Chang Portrait
Born (1954-11-19) November 19, 1954 (age 71)
Taiwan
EducationCalifornia Institute of Technology (B.S.)
Princeton University (M.S., Ph.D.)
Known forNonlinear waves on falling films; electrokinetic microfluidics; founding editor of Biomicrofluidics
SpouseMei-Chi Shaw
Awards
Scientific career
FieldsBiosensors, nanofluidics, fluid dynamics, microfluidics, electrokinetics
WorkplacesUniversity of Notre Dame
University of Houston
University of California, Santa Barbara
Doctoral students
Bolaji Aluko, Serafim Kalliadasis, Adrienne Minerick

Hsueh-Chia Chang ("Chia"; born November 19, 1954) is an American chemical engineer. He is Bayer Corporation Professor of Chemical and Biomolecular Engineering at the University of Notre Dame.[2]

His published work includes nonlinear waves on falling liquid films and electrokinetic flow in microfluidic and nanofluidic devices. In 1997 the American Physical Society elected him a fellow "for his deep and elegant contributions to the mathematics and to the physical understanding of nonlinear waves on thin films."[3] From 2006 to 2018 he was founding editor of the American Institute of Physics journal Biomicrofluidics.[4][5]

He is a fellow of the National Academy of Inventors (2020), of the American Institute for Medical and Biological Engineering (2025) and of the American Institute of Chemical Engineers (2026).[6][7][1]

Early life and education

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Chang was born on November 19, 1954, in Taiwan.[8] The AES Electrophoresis Society's award citation records that he grew up in Taiwan, Singapore, Malaysia and California.[9]

He received a B.S. in chemical engineering from the California Institute of Technology in 1976, an M.S. from Princeton University in 1977, and a Ph.D. from Princeton in 1980.[2]

Career

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Chang was an assistant professor of chemical engineering at the University of California, Santa Barbara from 1980 and an associate professor there from 1983. He taught at the University of Houston from 1984 to 1987, then joined Notre Dame.[9] He chaired the chemical engineering department from 1989 to 1995 and has held the Bayer Corporation chair since 1998.[2] He has a concurrent appointment in aerospace and mechanical engineering.[2]

Physics Today identified him in 2006 as director of Notre Dame's Center for Microfluidics and Medical Diagnostics.[4]

The 2020 NAI fellows volume states that he co-founded Aopia Biosciences.[6]

Research

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Falling films

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Chang's 1994 article in the Annual Review of Fluid Mechanics treats waves on a free-falling vertical film as an open-flow instability. It follows a sequence of nonlinear secondary transitions, from a selected monochromatic wave to irregular solitary humps.[10]

With Evgeny A. Demekhin and D. I. Kopelevich he constructed families of finite-amplitude stationary waves from a boundary-layer approximation of the film equations. The 1993 Journal of Fluid Mechanics paper tracks the downstream change from short, near-sinusoidal capillary waves to long solitary waves with tear-drop humps and front-running ripples.[11] The same collaboration produced the Elsevier monograph Complex Wave Dynamics on Thin Films (2002).[12]

The APS Division of Fluid Dynamics gave the 1991 François N. Frenkiel Award to Chang and Minquan Q. Cheng for a 1990 Physics of Fluids A paper that treated sideband stability of finite-amplitude waves by center-manifold projection.[13] The 1997 APS fellowship citation quoted above refers to the same thin-film line.[3]

A 1990 paper with J. Ratulowski argued that Marangoni stresses from trace impurities can thicken the residual film left by a long gas bubble in a capillary, and that this effect can account for the low-speed discrepancy with Bretherton's mobile-surface theory.[14]

Electrokinetics and diagnostic chips

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Cambridge University Press published Electrokinetically Driven Microfluidics and Nanofluidics, written with Leslie Yeo, in 2010. The book treats electro-osmotic and electrophoretic transport in confined geometries.[15]

In a 2008 Physical Review Letters paper, Gilad Yossifon and Chang reported that an ion-selective membrane driven into overlimiting current forms a depletion layer and a vortex instability on the side through which counterions enter.[16] A 2012 Annual Review of Fluid Mechanics article with Yossifon and Demekhin treats that microvortex as a hydrodynamic instability that raises ion flux into the membrane and produces the overlimiting-current bifurcation in the current-voltage curve. The review also notes that asymmetric entrances or viscous arrest of the vortex can be used to make a hydrodynamic nanofluidic diode.[17]

A 2015 Lab on a Chip paper from the group combined surface-acoustic-wave lysis of exosomes with an ion-exchange nanomembrane sensor for microRNA. In pancreatic-cancer cell media, the reported lysis rate was 38 percent and the membrane sensor's limit of detection was 2 pM; the assay time given is about 1.5 hours.[18] AIMBE's 2025 fellowship citation described later diagnostic work as "pioneering contributions to new diagnostic and microfluidic technologies, particularly for purifying and characterizing exosomes."[7]

Editorial work

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AIP announced the Biomicrofluidics appointment on May 24, 2006; the journal launched as an electronic-only, open-access title in January 2007.[4] Chang remained founding and chief editor until 2018. Yeo, co-editor from 2009, succeeded him.[5][19] Ronald Pethig edited a 2019 festschrift issue of the journal on that editorship and on Chang's electrokinetic papers.[20]

Awards and honors

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  • Fellow of the American Physical Society, 1997.[3]
  • Distinguished Visiting Fellow, Royal Academy of Engineering (United Kingdom), Imperial College London, 2011.[21]
  • Lifetime Achievement Award, AES Electrophoresis Society, 2019.[9]
  • Fellow of the National Academy of Inventors, 2020.[6]
  • Fellow of the American Institute for Medical and Biological Engineering, 2025.[7]
  • Fellow of the American Institute of Chemical Engineers, 2026.[1]

Personal life

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He is married to the mathematician Mei-Chi Shaw.[22]

Selected publications

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Books

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  • Chang, Hsueh-Chia; Demekhin, Evgeny A. (2002). Complex Wave Dynamics on Thin Films. Elsevier. ISBN 978-0-444-50970-3.
  • Chang, Hsueh-Chia; Yeo, Leslie Y. (2010). Electrokinetically Driven Microfluidics and Nanofluidics. Cambridge University Press. ISBN 978-0-521-86025-3.
  • Chang, Hsueh-Chia, ed. (2000). IUTAM Symposium on Nonlinear Waves in Multi-Phase Flow. Kluwer Academic. ISBN 978-0-7923-6454-2.

Articles

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References

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  1. 1 2 3 "Hsueh-Chia Chang receives national and local honors". Notre Dame Engineering. August 4, 2026. Retrieved September 22, 2026.
  2. 1 2 3 4 "Hsueh-Chia Chang". University of Notre Dame College of Engineering. Retrieved September 22, 2026.
  3. 1 2 3 "APS Fellow Archive". American Physical Society. Retrieved September 22, 2026. Chang, Hsueh Chia [1997], University of Notre Dame. Citation: For his deep and elegant contributions to the mathematics and to the physical understanding of nonlinear waves on thin films. Nominated by: Division of Fluid Dynamics.
  4. 1 2 3 "AIP Appoints Editor for Its New Open Access Journal — Biomicrofluidics". Physics Today. No. 7. July 19, 2006. doi:10.1063/PT.4.1581. Retrieved September 22, 2026.
  5. 1 2 Chang, Hsueh-Chia (2018). "Editorial: Farewell from the Founding and Chief Editor of Biomicrofluidics". Biomicrofluidics. 12 (6) 060401. doi:10.1063/1.5084549. PMC 6404945. PMID 30867864.
  6. 1 2 3 "2020 NAI Fellows" (PDF). National Academy of Inventors. 2020. Retrieved September 22, 2026.
  7. 1 2 3 "Hsueh-Chia Chang, Ph.D." American Institute for Medical and Biological Engineering. Retrieved September 22, 2026.
  8. ↑ "Curriculum Vitae: Hsueh-Chia Chang" (PDF). University of Notre Dame. Retrieved September 22, 2026.
  9. 1 2 3 "AES Lifetime Achievement Award". Federation of Analytical Chemistry and Spectroscopy Societies. Retrieved September 22, 2026.
  10. ↑ Chang, Hsueh-Chia (1994). "Wave evolution on a falling film". Annual Review of Fluid Mechanics. 26: 103–136. Bibcode:1994AnRFM..26..103C. doi:10.1146/annurev.fl.26.010194.000535.
  11. ↑ Chang, H.-C.; Demekhin, E. A.; Kopelevich, D. I. (1993). "Nonlinear evolution of waves on a falling film". Journal of Fluid Mechanics. 250: 433–480. doi:10.1017/S0022112093001481 (inactive September 28, 2026).{{cite journal}}: CS1 maint: DOI inactive as of September 2026 (link)
  12. ↑ Chang, Hsueh-Chia; Demekhin, Evgeny A. (2002). Complex Wave Dynamics on Thin Films. Elsevier. ISBN 978-0-444-50970-3.
  13. ↑ "François Frenkiel Award for Fluid Mechanics". American Physical Society, Division of Fluid Dynamics. Retrieved September 22, 2026.
  14. ↑ Ratulowski, J.; Chang, H.-C. (1990). "Marangoni effects of trace impurities on the motion of long gas bubbles in capillaries". Journal of Fluid Mechanics. 210: 303–328. Bibcode:1990JFM...210..303R. doi:10.1017/S0022112090001306.
  15. ↑ Chang, Hsueh-Chia; Yeo, Leslie Y. (2010). Electrokinetically Driven Microfluidics and Nanofluidics. Cambridge University Press. ISBN 978-0-521-86025-3.
  16. ↑ Yossifon, Gilad; Chang, Hsueh-Chia (2008). "Selection of nonequilibrium overlimiting currents: Universal depletion layer formation dynamics and vortex instability". Physical Review Letters. 101 (25) 254501. Bibcode:2008PhRvL.101y4501Y. doi:10.1103/PhysRevLett.101.254501. PMID 19113686.
  17. ↑ Chang, Hsueh-Chia; Yossifon, Gilad; Demekhin, Evgeny A. (2012). "Nanoscale electrokinetics and microvortices: How microhydrodynamics affects nanofluidic ion flux". Annual Review of Fluid Mechanics. 44 (1): 401–426. Bibcode:2012AnRFM..44..401C. doi:10.1146/annurev-fluid-120710-101046.
  18. ↑ Taller, Daniel; Richards, Katherine; Slouka, Zdenek; Senapati, Satyajyoti; Hill, Reginald; Go, David B.; Chang, Hsueh-Chia (2015). "On-chip surface acoustic wave lysis and ion-exchange nanomembrane detection of exosomal RNA for pancreatic cancer study and diagnosis". Lab on a Chip. 15 (7): 1656–1666. doi:10.1007/s12010-015-1503-8. PMID 25690351.
  19. ↑ Yeo, Leslie Y. (2019). "Engaging the microfluidics and nanofluidics community into the next decade". Biomicrofluidics. 13 (1) 010401. doi:10.1063/1.5088575. PMC 6404940. PMID 30867870.
  20. ↑ Pethig, Ronald (2019). "Festschrift for Professor Hsueh-Chia Chang". Biomicrofluidics. 13 (6) 060401. doi:10.1063/1.5141082. PMC 6908456. PMID 31867085.
  21. ↑ Cruise, Karla (April 1, 2025). "Hsueh-Chia Chang named Fellow of American Institute for Medical and Biological Engineering". Notre Dame Engineering. Retrieved September 22, 2026.
  22. ↑ Shaw, Mei-Chi (2015). "A Woman Mathematician's Journey". In Casazza, Peter; Krantz, Steven G.; Ruden, R. (eds.). I, Mathematician. Mathematical Association of America. pp. 227–249.
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