Draft:David Cortez
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Comment: In accordance with Wikipedia's Conflict of interest guideline, I disclose that I have a conflict of interest regarding the subject of this article. Mitchell2526 (talk) 16:43, 31 August 2026 (UTC)
David Cortez is an the Hortense B. Ingram Professor of Cancer Research, Professor and Chair of Biochemistry at Vanderbilt University School of Medicine, and Associate Director for Basic Research at the Vanderbilt-Ingram Cancer Center.[1][2] He is also affiliated with the Vanderbilt Institute of Chemical Biology. [3]
He has also received the Howard Temin Award.[4]
Early life and education
[edit]Cortez earned his Bachelor of Science degree in Biochemistry and Biology from the University of Illinois at Urbana-Champaign. He received his Ph.D. in Molecular Cancer Biology from Duke University. He completed postdoctoral training at Baylor College of Medicine as a Jane Coffin Childs Fellow.[5][6][2]
Career
[edit]Cortez joined Vanderbilt University in 2002 as a faculty member in the Department of Biochemistry. (TCL, ASbMB) He became an Associate Professor in 2007 and Professor in 2009, and became Chair of the Department of Biochemistry in 2021.[2] [5]
He also serves as Associate Director for Basic Research at the Vanderbilt-Ingram Cancer Center and previously as Co-Leader of the Genome Maintenance Program.[7] [8] [9]
Cortez’s served as director of Graduate Studies in the Department of Biochemistry at Vanderbilt University for eight years. [7] [8]
Research
[edit]Cortez’s research studies DNA and the understanding of DNA damage, damage response, and the replication and repair to develop more effective treatments for cancer and other diseases. [1] [2] [10]
His laboratory studies the mechanisms in maintaining genome integrity in normal and cancer cells and promoting the complete and accurate replication of the genome.[1]
In 2019, Cortez and colleagues discovered a new DNA Repair Pathway, in which DNA repair pathway protein shields sites of damage to avoid mutation and maintain genome integrity. This came after his team and colleagues reported a new DNA repair mechanism, involving a protein called HMCES.[11] [12] [13] [14]
Honors and awards
[edit]Cortez’s awards and honors include the Hans Neurath Award from the Protein Society[15], a Pew Scholar Award from the Pew Charitable Trusts[10], and was recognized for Advancing Science in 2017 by the Americas Association for the Advancement of Science. [16]
Selected publications
[edit]- Cortez, D.; Guntuku, S.; Qin, J.; Elledge, S. J. (2001). "ATR and ATRIP: partners in checkpoint signaling". Science. 294 (5547): 1713–1716. doi:10.1126/science.1065521. PMID 11721054.
- Nam, E. A.; Cortez, D. (2011). "ATR signalling: more than meeting at the fork". Biochemical Journal. 436 (3): 527–536. doi:10.1042/BJ20102162. PMID 21615334.
- Bhat, K. P.; Cortez, D. (2018). "RPA and RAD51: fork reversal, fork protection, and genome stability". Nature Structural & Molecular Biology. 25 (6): 446–453. doi:10.1038/s41594-018-0075-z. PMID 29807999.
- Sirbu, B. M.; Cortez, D. (2013). "DNA damage response: three levels of DNA repair regulation". Cold Spring Harbor Perspectives in Biology. 5 (8): a012724. doi:10.1101/cshperspect.a012724. PMID 23813586.
- Cortez, D. (2017). "Proteomic analyses of the eukaryotic replication machinery". Methods in Enzymology. 591: 33–53. doi:10.1016/bs.mie.2017.03.002. PMID 28645376.
- Complete publication list: David K. Cortez publications on PubMed
References
[edit]- 1 2 3 "Biochemistry-1".
- 1 2 3 4 "Breast Cancer Research Foundation".
- ↑ "VICB".
- ↑ News, Vanderbilt Health (2020-12-08). "Cortez named interim chair of the Department of Biochemistry; York named Impossible Foods chief science officer". Vanderbilt Health News. Retrieved 2026-08-31.
{{cite web}}:|last=has generic name (help) - 1 2 "ASBMB".
- ↑ "Duke University".
- 1 2 "Vanderbilt Health".
- 1 2 "The Cancer Letter".
- ↑ "BCHM -2".
- 1 2 "Pew".
- ↑ "Life Science".
- ↑ "Nature".
- ↑ "Phys.org".
- ↑ "Biotecnika".
- ↑ "Eurek Alert".
- ↑ "AAAS".