Edge Rewrite
everything Source code View original
// HTMLRewriter · presentation

This page was redesigned at the edge.

Cloudflare fetched the original article and streamed it through HTMLRewriter to apply an entirely new visual system without rebuilding the source page.

// request.cf · coarse context

A page that knows where it met you.

Only coarse request metadata is shown. This demo does not display or persist visitor IP addresses.

Country
US
Cloudflare location
CMH
Connection
HTTP/2
Language
Not provided

Ray ID: a22f89339a167089

Jump to content

Draft:Daniel Goldowitz

From Wikipedia, the free encyclopedia


Overview

[edit]

Dr. Dan Goldowitz is a developmental neurobiologist and a key member of research communities that study brain development. Findings from his studies have led to the development and application of various treatments for people with neurodevelopmental conditions.

For the past five decades, Goldowitz has undertaken research on infant and childhood brain development in the US, Sweden and Canada. He is currently Professor Emeritus at the University of British Columbia (UBC) in the Faculty of Medicine, Department of Medical Genetics.

Background

[edit]

Goldowitz grew up in Los Angeles and completed his interdisciplinary undergraduate studies at Antioch College and the University of California, Santa Cruz. He received his PhD in Psychobiology at the University of California at Irvine with a thesis that focused on the plasticity of the adult central nervous system in response to lesions. His postdoctoral work at Harvard Children’s Hospital in Boston, the Karolinska Institute in Stockholm, and the University of Utah School of Medicine in Salt Lake City focused on the development of the nervous system.

Goldowitz subsequently took a position as assistant professor in the Department of Anatomy and Developmental Biology at the Jefferson Medical College in Philadelphia before continuing his research at both the University of Tennessee Health Science Centre and the Children's Hospital Research Institute at the University of British Columbia.

Major Research and Accomplishments

[edit]

Goldowitz has made contributions to the fields of neuroscience and neurogenetics, and he has led community organization efforts to focus resources in these areas with an emphasis on infant and child brain development.

Developmental Neurobiology and Neurogenetics

[edit]

During his early years, Goldowitz used experimental mouse chimeras to study cell lineage in the forming brain [1] [2] [3] and to investigate how mutant genes target specific cells during development of the cerebellum. [4] This research proved the effectiveness of the chimera technology by demonstrating the technique's ability to illuminate the cells intrinsically affected by the weaver mutation. Importantly, the chimera technology identified the cerebellar granule cell as the structure affected by the mutation rather than the Bergmann glia cell, which had been previously hypothesized. [5] Goldowitz and colleagues were then able to show how this mutation could be "cured" by mutating the receptor that the weaver gene affected. [6]

The cerebellum is important for motor co-ordination, planning and learning and is implicated in several neurodevelopmental conditions, including autism spectrum disorder. This was the mainstay of Goldowitz's work as an assistant professor at the Jefferson Medical College. Continuation of the work branched into studying the role of genes in behaviour. Goldowitz also served as an early president of the newly founded organization, IBANGS – the International Behavioural and Neural Genetics Society.

Goldowitz worked with other researchers at University of Tennessee Health Science Center (UTHSC) to obtain NIH funding for projects to bring science education to the K-12 grades. In 2004, he was awarded an endowed chair of Neurosciences at UTHSC. During his time in Tennessee, he also formed two other research consortia – 1) Mapping Cerebellar Development in Time & Space funded by the National Institute of Child Health & Human Development and 2) INIA/ The Integrative Neuroscience Initiative on Alcoholism funded by the National Institute on Alcohol Abuse & Alcoholism. [7] The findings from these efforts have been made accessible in publicly available datasets. [8] [9] [10]

These efforts also resulted in national and international collaborations that Goldowitz brought to Canada (the Centre for Molecular Medicine and Therapeutics at the BC Children’s Hospital Research Institute at UBC) in 2007. At UBC he was awarded a Tier 1 Canada Research Chair in Developmental Neurogenetics. He maintains strong NIH-CIHR- and foundation-funded research programs in the genetics of brain development and function.

Community Organization

[edit]

With his move to UTHSC in Memphis in 1989, Goldowitz took on the role of community organizer of researchers generally interested in the genetic basis of brain function, and more specifically, the development and function of the cerebellum. He was instrumental in organizing researchers across the state of Tennessee, as part of the human genome project, to use the mouse as a model organism in order to identify specific gene functions.

The Tennessee Mouse Genome Consortium resulted from these efforts. It was awarded one of three US National Institute of Health (NIH) awards (amounting to about US$13,000,000 over 5 years) for the purpose of understanding the role of genes in brain functions. [11] [12] [13] This success led the University of Tennessee system to create a US$6,000,000 program to fund a Centre of Excellence in Genomics and Bioinformatics proposed by Goldowitz and his colleague Rob Willliams.

While in Canada, Goldowitz founded a research consortium with a focus on brain development and established the research network, NeuroDevNet, a trans-Canadian Network of Centres of Excellence (NCE) for research on brain development. He led the successful submission of an application for one of the federally funded NCEs, which brought NeuroDevNet [rebranded as Kids Brain Health Network (KBHN)] a second 5-year cycle of funding with Goldowitz as the Scientific Director. [14]

More recently, Goldowitz co-led a successful application to the Canadian Institutes of Health Research (CIHR) under Canada’s Strategies for Patient-Oriented Research (SPOR) with a mandate to establish a chronic disease network focused neurodevelopmental disabilities. CHILD-BRIGHT (Child Health Innovations Limiting Disability-Brain Research Improving Growth Health Trajectories) is a national network that aims to improve life outcomes for children with brain-based developmental disabilities and their families. Within this Network, Goldowitz is a co-Principle Investigator and leads the Training Core which is tasked with developing the training program for multiple stakeholder groups (patients/families, health care providers, researchers, and policy makers).

Publications

[edit]

Dr. Goldowitz has 218 PubMed citations from the MEDLINE database related to his scientific publications. He is also the co-editor of two books:

  • “Neurodevelopmental Pediatrics”, (2023) Eds:DD. Eisenstat, T. Oberlander, D. Goldowitz, J. Yager.
  • "Techniques for the Genetic Analysis of Brain and Behavior: Focus on the Mouse.", (1992) Elsevier Science Ltd, Netherlands.

Awards

[edit]
  • Methodist Hospital Foundation Endowment Professor,University of Tennessee Health Science Center (2004-2007)
  • President, International Behavioural and Neural Genetics Society – 2007
  • Applebaum Visiting Lecturer, University of Florida, Gainesville, Nov 4-9, 2009
  • Canadian Research Chair in Developmental Neurogenetics, Tier 1 – 2007 – 2014, 2014 – 2021
  • Visiting Hannah Distinguished Professor at Michigan State University, 2016-7

References

[edit]
  1. ^ Goldowitz, Dan (1989). "Cell allocation in mammalian CNS formation: Evidence from murine interspecies aggregation chimeras". Neuron. 3 (6): 705–713. doi:10.1016/0896-6273(89)90239-0. PMID 2642015.
  2. ^ Martin, Loren A. (May 1, 2002). "Clonal architecture of the mouse hippocampus". J Neurosci. 22 (9): 3520–3530. doi:10.1523/JNEUROSCI.22-09-03520.2002. PMC 6758370. PMID 11978829.
  3. ^ Hamre, Kristin M. (1997). "Meander tail acts intrinsic to granule cell precursors to disrupt cerebellar development: analysis of meander tail chimeric mice". Development. 124 (21): 4201–4212. doi:10.1242/dev.124.21.4201. PMID 9334269.
  4. ^ Goldowitz, Dan (September 1998). "The cells and molecules that make a cerebellum". Trends Neurosci. 21 (9): 375–382. doi:10.1016/s0166-2236(98)01313-7. PMID 9735945.
  5. ^ Goldowitz, Dan (1989). "The weaver granuloprival phenotype is due to intrinsic action of the mutant locus In granule cells: Evidence from homozygous weaver chimeras". Neuron. 2 (6): 1565–1575. doi:10.1016/0896-6273(89)90045-7. PMID 2627379.
  6. ^ Jensen, Patricia (September 1999). "Rescue of Cerebellar Granule Cells from Death in weaver NR1 Double Mutants". J Neuroscience. 19 (18): 7991–7998. doi:10.1523/jneurosci.19-18-07991.1999. PMC 6782480. PMID 10479699.
  7. ^ "Concept Clearance: The Integrative Neuroscience Initiative on Alcoholism (INIA) - Renewal | National Institute on Alcohol Abuse and Alcoholism (NIAAA)".
  8. ^ FANTOM Consortium (2014). "A promoter-level mammalian expression atlas". Nature. 507 (7493): 462–470. Bibcode:2014Natur.507..462T. doi:10.1038/nature13182. PMC 4529748. PMID 24670764.
  9. ^ Yeung, Joanna (August 31, 2016). "A Novel and Multivalent Role of Pax6 in Cerebellar Development". J Neurosci. 36 (35): 9057–9069. doi:10.1523/JNEUROSCI.4385-15.2016. PMC 5005719. PMID 27581449.
  10. ^ Ramirez, Miguel (August 9, 2022). "Temporal analysis of enhancers during mouse cerebellar development reveals dynamic and novel regulatory functions". eLife. 11 e74207. doi:10.7554/eLife.74207. PMC 9398453. PMID 35942939.
  11. ^ Jablonski, Monica M. (2005). "The Tennessee Mouse Genome Consortium: identification of ocular mutants". Vis Neurosci. 22 (5): 595–604. doi:10.1017/S0952523805225087. PMID 16332270.
  12. ^ Bult, Carol (2004). "A genome end-game: understanding gene function in the nervous system". Nature Neuroscience. 7 (5): 484–485. doi:10.1038/nn0504-484. PMC 3770737. PMID 15114363.
  13. ^ Goldowitz, Dan (December 20, 2004). "Large-scale mutagenesis of the mouse to understand the genetic bases of nervous system structure and function". Molecular Brain Research. 132 (2): 105–115. doi:10.1016/j.molbrainres.2004.09.016. PMC 3773686. PMID 15582151.
  14. ^ Goldowitz, Dan (2011). "The NeuroDevNet vision". Seminars in Pediatric Neurology. 18 (1): 2–4. doi:10.1016/j.spen.2011.02.007. PMID 21575833.
[edit]


Retrieved from "https://en.wikipedia.org/w/index.php?title=Draft:Daniel_Goldowitz&oldid=1357250367"