// Workers AI · dad joke modeWhy did Dimethylcurcumin go to therapy? It had a compound problem.

Dimethylcurcumin

Clinical data
Other names	ASC-J9; GO-Y025
Routes of administration	Topical
Drug class	Nonsteroidal antiandrogen; Selective androgen receptor degrader
Identifiers
IUPAC name (1E,4Z,6E)-1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxyhepta-1,4,6-trien-3-one
CAS Number	52328-98-0
PubChem CID	6477182
ChemSpider	4978553
UNII	D60XLY608D
CompTox Dashboard (EPA)	DTXSID101316356 DTXSID10200352, DTXSID101316356
Chemical and physical data
Formula	C23H24O6
Molar mass	396.439 g·mol−1
3D model (JSmol)	Interactive image
SMILES COC1=C(C=C(C=C1)/C=C/C(=C/C(=O)/C=C/C2=CC(=C(C=C2)OC)OC)/O)OC
InChI InChI=1S/C23H24O6/c1-26-20-11-7-16(13-22(20)28-3)5-9-18(24)15-19(25)10-6-17-8-12-21(27-2)23(14-17)29-4/h5-15,24H,1-4H3/b9-5+,10-6+,18-15- Key:ZMGUKFHHNQMKJI-CIOHCNBKSA-N

Dimethylcurcumin (development code ASC-J9) is a nonsteroidal antiandrogen and a synthetic curcuminoid.

In vitro, it is an androgen receptor (AR) inhibitor and shows antiandrogenic activity, although its mechanism of action and effects differ from those of conventional antiandrogens; it is not an antagonist of the AR and instead appears to act as a selective degradation enhancer of certain subpopulations of the AR, for instance those present in the prostate gland.

See also

• List of investigational sex-hormonal agents § Androgenics
• Rosolutamide (ASC-JM17, JM17, ALZ-003)