// Workers AI · dad joke modeWhat did Derlin-3 say to Derlin-2? You're one less.

DERL3
Identifiers
Aliases	DERL3, C22orf14, IZP6, LLN2, derlin-3, derlin 3
External IDs	OMIM: 610305; MGI: 1917627; HomoloGene: 41566; GeneCards: DERL3; OMA:DERL3 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	23,839,128 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	75,895,941 bp
RNA expression pattern
	Top expressed in
	bone marrow cell; ; duodenum; ; tonsil; ; epithelium of colon; ; appendix; ; body of pancreas; ; lymph node; ; spleen; ; mucosa of transverse colon; ; rectum;
	Top expressed in
	salivary gland; ; submandibular gland; ; lacrimal gland; ; parotid gland; ; zygote; ; seminal vesicula; ; primary oocyte; ; secondary oocyte; ; pyloric antrum; ; epithelium of stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; integral component of endoplasmic reticulum membrane; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; signal recognition particle receptor complex; signal recognition particle;
Biological process	endoplasmic reticulum unfolded protein response; negative regulation of retrograde protein transport, ER to cytosol; protein N-linked glycosylation via asparagine; ubiquitin-dependent ERAD pathway;
	Sources:Amigo / QuickGO
Orthologs
	91319
	70377
	ENSG00000274437; ENSG00000099958
	ENSMUSG00000009092
	Q96Q80
	Q9D8K3
	NM_001002862; NM_001135751; NM_198440; NM_001363072
	NM_024440
	NP_001002862; NP_001129223; NP_940842; NP_001350001
	NP_077760; NP_001345912; NP_001345913; NP_001345914
	Wikidata
View/Edit Human	View/Edit Mouse

Derlin-3 is a protein that in humans is encoded by the DERL3 gene.^[5]^[6]

References

1 2 3 ENSG00000099958 GRCh38: Ensembl release 89: ENSG00000274437, ENSG00000099958 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000009092 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lilley BN, Ploegh HL (Jun 2004). "A membrane protein required for dislocation of misfolded proteins from the ER". Nature. 429 (6994): 834–40. Bibcode:2004Natur.429..834L. doi:10.1038/nature02592. PMID 15215855. S2CID 29483256.
↑ "Entrez Gene: DERL3 Der1-like domain family, member 3".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Oda Y, Okada T, Yoshida H, et al. (2006). "Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation". J. Cell Biol. 172 (3): 383–93. doi:10.1083/jcb.200507057. PMC 2063648. PMID 16449189.
Wang X, Bolotin D, Chu DH, et al. (2006). "AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis". J. Cell Biol. 172 (3): 409–21. doi:10.1083/jcb.200510002. PMC 2063650. PMID 16449191.
Morrison JI, Lööf S, He P, Simon A (2006). "Salamander limb regeneration involves the activation of a multipotent skeletal muscle satellite cell population". J. Cell Biol. 172 (3): 433–40. doi:10.1083/jcb.200509011. PMC 2063652. PMID 16449193.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 ENSG00000099958 GRCh38: Ensembl release 89: ENSG00000274437, ENSG00000099958 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000009092 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15215855-5] Lilley BN, Ploegh HL (Jun 2004). "A membrane protein required for dislocation of misfolded proteins from the ER". Nature. 429 (6994): 834–40. Bibcode:2004Natur.429..834L. doi:10.1038/nature02592. PMID 15215855. S2CID 29483256.

[entrez-6] "Entrez Gene: DERL3 Der1-like domain family, member 3".

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// Workers AI · dad joke modeWhat did Derlin-3 say to Derlin-2? You're one less.

See also

References

Further reading