// Workers AI · dad joke modeWhat did Dabogratinib say? "I'm a dab at healing

dabogratinib
INN: dabogratinib

Identifiers
IUPAC name 5-[(1R)-1-(3,5-dichloro-4-pyridinyl)ethoxy]-3-[6-(2-methylsulfonyl-2,6-diazaspiro[3.3]heptan-6-yl)-3-pyridinyl]-1H-indazole
CAS Number	2800223-30-5
PubChem CID	170647464
IUPHAR/BPS	13809
UNII	FH245S2JZJ
ChEMBL	ChEMBL5595500
PDB ligand	A1AV2 (PDBe, RCSB PDB)
Chemical and physical data
Formula	C25H24Cl2N6O3S
Molar mass	559.47 g·mol−1
3D model (JSmol)	Interactive image
SMILES C[C@H](C1=C(C=NC=C1Cl)Cl)OC2=CC3=C(C=C2)NN=C3C4=CN=C(C=C4)N5CC6(C5)CN(C6)S(=O)(=O)C
InChI InChI=InChI=1S/C25H24Cl2N6O3S/c1-15(23-19(26)9-28-10-20(23)27)36-17-4-5-21-18(7-17)24(31-30-21)16-3-6-22(29-8-16)32-11-25(12-32)13-33(14-25)37(2,34)35/h3-10,15H,11-14H2,1-2H3,(H,30,31)/t15-/m1/s1 Key:JOAFWIHZEBKYQK-OAHLLOKOSA-N

Dabogratinib is an investigational new drug that is being evaluated by TYRA Biosciences for the treatment of achondroplasia and solid tumors. It is a fibroblast growth factor receptor 3 receptor antagonist.