DRG1

DRG1
Identifiers
Aliases	DRG1, NEDD3, developmentally regulated GTP binding protein 1
External IDs	OMIM: 603952; MGI: 1343297; HomoloGene: 3060; GeneCards: DRG1; OMA:DRG1 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EKI
Gene location (Human)
Chr.	Chromosome 22 (human)
End	31,530,634 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	3,216,415 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; male germ cell; ; triceps brachii muscle; ; glutes; ; sperm; ; deltoid muscle; ; tibialis anterior muscle; ; Skeletal muscle tissue of rectus abdominis; ; quadriceps femoris muscle;
	Top expressed in
	medial ganglionic eminence; ; spermatocyte; ; blastocyst; ; spermatid; ; morula; ; morula; ; embryo; ; epiblast; ; internal carotid artery; ; ventricular zone;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; GTP binding; transcription factor binding; protein binding; identical protein binding; GTPase activity; microtubule binding; hydrolase activity; potassium ion binding; metal ion binding;
Cellular component	cytoplasm; polysome; membrane; cytosol; nuclear body; nucleus;
Biological process	multicellular organism development; transcription, DNA-templated; cytoplasmic translation; positive regulation of microtubule polymerization; regulation of mitotic spindle assembly;
	Sources:Amigo / QuickGO
Orthologs
	4733
	13494
	ENSG00000185721
	ENSMUSG00000020457
	Q9Y295
	P32233
	NM_004147
	NM_007879
	NP_004138
	NP_031905
	Wikidata
View/Edit Human	View/Edit Mouse

Developmentally-regulated GTP-binding protein 1 is a protein that in humans is encoded by the DRG1 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000185721 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020457 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Schenker T, Lach C, Kessler B, Calderara S, Trueb B (Nov 1994). "A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts". J Biol Chem. 269 (41): 25447–53. doi:10.1016/S0021-9258(18)47271-7. PMID 7929244.
↑ Sazuka T, Tomooka Y, Ikawa Y, Noda M, Kumar S (Dec 1992). "DRG: a novel developmentally regulated GTP-binding protein". Biochem Biophys Res Commun. 189 (1): 363–70. doi:10.1016/0006-291X(92)91567-A. PMID 1449490.
↑ "Entrez Gene: DRG1 developmentally regulated GTP binding protein 1".

Sazuka T, Kinoshita M, Tomooka Y, et al. (1992). "Expression of DRG during murine embryonic development". Biochem. Biophys. Res. Commun. 189 (1): 371–7. doi:10.1016/0006-291X(92)91568-B. PMID 1280421.
Mahajan MA, Park ST, Sun XH (1996). "Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins". Oncogene. 12 (11): 2343–50. PMID 8649774.
Zhao XF, Aplan PD (1999). "SCL binds the human homologue of DRG in vivo". Biochim. Biophys. Acta. 1448 (1): 109–14. doi:10.1016/s0167-4889(98)00129-3. PMID 9824680.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Li B, Trueb B (2000). "DRG represents a family of two closely related GTP-binding proteins". Biochim. Biophys. Acta. 1491 (1–3): 196–204. doi:10.1016/s0167-4781(00)00025-7. PMID 10760581.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bandyopadhyay S, Pai SK, Gross SC, et al. (2003). "The Drg-1 gene suppresses tumor metastasis in prostate cancer". Cancer Res. 63 (8): 1731–6. PMID 12702552.
Bandyopadhyay S, Pai SK, Hirota S, et al. (2004). "Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression". Oncogene. 23 (33): 5675–81. doi:10.1038/sj.onc.1207734. PMID 15184886. S2CID 24392094.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Bandyopadhyay S, Wang Y, Zhan R, et al. (2007). "The tumor metastasis suppressor gene Drg-1 down-regulates the expression of activating transcription factor 3 in prostate cancer". Cancer Res. 66 (24): 11983–90. doi:10.1158/0008-5472.CAN-06-0943. PMID 17178897.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000185721 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020457 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7929244-5] Schenker T, Lach C, Kessler B, Calderara S, Trueb B (Nov 1994). "A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts". J Biol Chem. 269 (41): 25447–53. doi:10.1016/S0021-9258(18)47271-7. PMID 7929244.

[pmid1449490-6] Sazuka T, Tomooka Y, Ikawa Y, Noda M, Kumar S (Dec 1992). "DRG: a novel developmentally regulated GTP-binding protein". Biochem Biophys Res Commun. 189 (1): 363–70. doi:10.1016/0006-291X(92)91567-A. PMID 1449490.

[entrez-7] "Entrez Gene: DRG1 developmentally regulated GTP binding protein 1".

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DRG1

References

Further reading