DPP6

DPP6
Identifiers
Aliases	DPP6, DPPX, VF2, MRD33, DPL1, dipeptidyl peptidase like 6
External IDs	OMIM: 126141; MGI: 94921; GeneCards: DPP6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XFD
Gene location (Human) Chr. Chromosome 7 (human) Band 7q36.2 Start 153,887,097 bp End 154,894,285 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 B1|5 12.92 cM Start 27,022,201 bp End 27,932,503 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 endothelial cell pons lateral nuclear group of thalamus primary visual cortex superior frontal gyrus postcentral gyrus entorhinal cortex Region I of hippocampus proper Top expressed in dentate gyrus of hippocampal formation granule cell cerebellar cortex habenula superior frontal gyrus primary visual cortex dorsomedial hypothalamic nucleus paraventricular nucleus of hypothalamus superior colliculus supraoptic nucleus ventral tegmental area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function potassium channel regulator activity serine-type peptidase activity dipeptidyl-peptidase activity Cellular component integral component of membrane plasma membrane membrane voltage-gated potassium channel complex Biological process protein localization to plasma membrane regulation of potassium ion transmembrane transport proteolysis Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 1804 13483 Ensembl ENSG00000130226 ENSG00000282974 ENSMUSG00000061576 UniProt P42658 Q8IYG9 Q9Z218 RefSeq (mRNA) NM_001039350 NM_001290252 NM_001290253 NM_001936 NM_130797 NM_001136060 NM_001198886 NM_010075 NM_207282 RefSeq (protein) NP_001034439 NP_001277181 NP_001277182 NP_001927 NP_570629 NP_001351426 NP_001351427 NP_001351428 NP_001351429 NP_001351430 NP_001351431 NP_001277182.1 NP_570629.2 NP_001034439.1 NP_001277181.1 NP_001927.3 NP_570629.2 NP_001129532 NP_001185815 NP_034205 NP_997165 Location (UCSC) Chr 7: 153.89 – 154.89 Mb Chr 5: 27.02 – 27.93 Mb PubMed search
Wikidata
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Dipeptidyl aminopeptidase-like protein 6 is a protein that in humans is encoded by the DPP6 gene.

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Further reading

• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, et al. (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
• Yokotani N, Doi K, Wenthold RJ, Wada K (1993). "Non-conservation of a catalytic residue in a dipeptidyl aminopeptidase IV-related protein encoded by a gene on human chromosome 7". Human Molecular Genetics. 2 (7): 1037–1039. doi:10.1093/hmg/2.7.1037. PMID 8103397.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Sanger Centre T, Washington University Genome Sequencing Cente T (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Kin Y, Misumi Y, Ikehara Y (2001). "Biosynthesis and characterization of the brain-specific membrane protein DPPX, a dipeptidyl peptidase IV-related protein". Journal of Biochemistry. 129 (2): 289–295. doi:10.1093/oxfordjournals.jbchem.a002856. PMID 11173531.
• Nadal MS, Ozaita A, Amarillo Y, Vega-Saenz de Miera E, Ma Y, Mo W, et al. (February 2003). "The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels". Neuron. 37 (3): 449–461. doi:10.1016/S0896-6273(02)01185-6. PMID 12575952. S2CID 11494299.
• Schmitt-Ulms G, Hansen K, Liu J, Cowdrey C, Yang J, DeArmond SJ, et al. (June 2004). "Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues". Nature Biotechnology. 22 (6): 724–731. doi:10.1038/nbt969. PMID 15146195. S2CID 36630738.
• Strop P, Bankovich AJ, Hansen KC, Garcia KC, Brunger AT (October 2004). "Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family". Journal of Molecular Biology. 343 (4): 1055–1065. doi:10.1016/j.jmb.2004.09.003. PMID 15476821.
• Zagha E, Ozaita A, Chang SY, Nadal MS, Lin U, Saganich MJ, et al. (May 2005). "DPP10 modulates Kv4-mediated A-type potassium channels". The Journal of Biological Chemistry. 280 (19): 18853–18861. doi:10.1074/jbc.M410613200. PMID 15671030.
• Radicke S, Cotella D, Graf EM, Ravens U, Wettwer E (June 2005). "Expression and function of dipeptidyl-aminopeptidase-like protein 6 as a putative beta-subunit of human cardiac transient outward current encoded by Kv4.3". The Journal of Physiology. 565 (Pt 3): 751–756. doi:10.1113/jphysiol.2005.087312. PMC 1464568. PMID 15890703.
• Ren X, Hayashi Y, Yoshimura N, Takimoto K (2005). "Transmembrane interaction mediates complex formation between peptidase homologues and Kv4 channels". Molecular and Cellular Neurosciences. 29 (2): 320–332. doi:10.1016/j.mcn.2005.02.003. PMID 15911355. S2CID 34065803.
• Jerng HH, Kunjilwar K, Pfaffinger PJ (2006). "Multiprotein assembly of Kv4.2, KChIP3 and DPP10 produces ternary channel complexes with ISA-like properties". The Journal of Physiology. 568 (Pt 3): 767–788. doi:10.1113/jphysiol.2005.087858. PMC 1464192. PMID 16123112.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Nadal MS, Amarillo Y, Vega-Saenz de Miera E, Rudy B (2006). "Differential characterization of three alternative spliced isoforms of DPPX". Brain Research. 1094 (1): 1–12. doi:10.1016/j.brainres.2006.03.106. PMID 16764835. S2CID 33513405.