// Workers AI · dad joke modeWhat did DOM3Z say to its date? "You're a dom-inant match

DXO
Identifiers
Aliases	DXO, DOM3L, DOM3Z, NG6, RAI1, decapping exoribonuclease
External IDs	OMIM: 605996; MGI: 1890444; HomoloGene: 38061; GeneCards: DXO; OMA:DXO - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3FQI, 3FQJ, 4J7L, 4J7M, 4J7N
Gene location (Human)
Chr.	Chromosome 6 (human)
End	31,972,290 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	35,058,209 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; pituitary gland; ; anterior pituitary; ; right hemisphere of cerebellum; ; left adrenal cortex; ; right lobe of liver; ; right adrenal gland; ; right adrenal cortex; ; left ovary;
	Top expressed in
	spermatocyte; ; spermatid; ; tail of embryo; ; otic vesicle; ; internal carotid artery; ; external carotid artery; ; granulocyte; ; yolk sac; ; saccule; ; right kidney;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; nuclease activity; 5'-3' exonuclease activity; exonuclease activity; mRNA binding; RNA pyrophosphohydrolase activity; hydrolase activity; magnesium ion binding; metal ion binding; RNA binding;
Cellular component	plasma membrane; nucleus; cytosol;
Biological process	nuclear mRNA surveillance; mRNA catabolic process; RNA destabilization; nucleic acid phosphodiester bond hydrolysis;
	Sources:Amigo / QuickGO
Orthologs
	1797
	112403
ENSG00000204348; ENSG00000236765; ENSG00000224313; ENSG00000206346; ENSG00000225682;
	ENSG00000234798
	ENSMUSG00000040482
	O77932
	O70348
	NM_005510; NM_001371205; NM_001371206
	NM_001163770; NM_033613
	NP_005501; NP_001358134; NP_001358135
	NP_001157242; NP_291091
	Wikidata
View/Edit Human	View/Edit Mouse

Protein Dom3Z is a protein that in humans is encoded by the gene DXO (previously DOM3Z).^[5]^[6]

This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The function of its protein product is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotes suggests that this may be a housekeeping gene.^[6]

References

1 2 3 ENSG00000236765, ENSG00000224313, ENSG00000206346, ENSG00000225682, ENSG00000234798 GRCh38: Ensembl release 89: ENSG00000204348, ENSG00000236765, ENSG00000224313, ENSG00000206346, ENSG00000225682, ENSG00000234798 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040482 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Yang Z, Shen L, Dangel AW, Wu LC, Yu CY (Dec 1998). "Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA". Genomics. 53 (3): 338–47. doi:10.1006/geno.1998.5499. PMID 9799600.
1 2 "Entrez Gene: DOM3Z dom-3 homolog Z (C. elegans)".

Yu CY (1999). "Molecular genetics of the human MHC complement gene cluster". Exp. Clin. Immunogenet. 15 (4): 213–30. doi:10.1159/000019075. PMID 10072631. S2CID 25061446.
Yang Z, Yu CY (2000). "Organizations and gene duplications of the human and mouse MHC complement gene clusters". Exp. Clin. Immunogenet. 17 (1): 1–17. doi:10.1159/000019119. PMID 10686478. S2CID 45164668.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 ENSG00000236765, ENSG00000224313, ENSG00000206346, ENSG00000225682, ENSG00000234798 GRCh38: Ensembl release 89: ENSG00000204348, ENSG00000236765, ENSG00000224313, ENSG00000206346, ENSG00000225682, ENSG00000234798 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040482 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9799600-5] Yang Z, Shen L, Dangel AW, Wu LC, Yu CY (Dec 1998). "Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA". Genomics. 53 (3): 338–47. doi:10.1006/geno.1998.5499. PMID 9799600.

[entrez-6] 1 2 "Entrez Gene: DOM3Z dom-3 homolog Z (C. elegans)".

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// Workers AI · dad joke modeWhat did DOM3Z say to its date? "You're a dom-inant match

References

Further reading