DNER

DNER
Identifiers
Aliases	DNER, UNQ26, bet, delta/notch like EGF repeat containing
External IDs	OMIM: 607299; MGI: 2152889; GeneCards: DNER
Gene location (Human)
Chr.	Chromosome 2 (human)
End	229,714,555 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	84,673,942 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; cerebellar vermis; ; pars reticulata; ; pars compacta; ; parotid gland; ; subthalamic nucleus; ; external globus pallidus; ; inferior ganglion of vagus nerve; ; superior vestibular nucleus; ; internal globus pallidus;
	Top expressed in
	lobe of cerebellum; ; cerebellar vermis; ; ventromedial nucleus; ; barrel cortex; ; piriform cortex; ; habenula; ; mammillary body; ; ventral tegmental area; ; deep cerebellar nuclei; ; substantia nigra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	clathrin binding; calcium ion binding; protein binding; transmembrane signaling receptor activity; Notch binding;
Cellular component	integral component of membrane; soma; plasma membrane; dendrite; early endosome; membrane;
Biological process	Notch receptor processing; synapse assembly; central nervous system development; neuron migration; endocytosis; glial cell differentiation; skeletal muscle fiber development; Notch signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	92737
	227325
	ENSG00000187957
	ENSMUSG00000036766
	Q8NFT8
	Q8JZM4
	NM_139072
	NM_152915
	NP_620711
	NP_690879
	Wikidata
View/Edit Human	View/Edit Mouse

Delta and Notch-like epidermal growth factor-related receptor is a protein that in humans is encoded by the DNER gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000187957 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036766 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Eiraku M, Hirata Y, Takeshima H, Hirano T, Kengaku M (July 2002). "Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons". The Journal of Biological Chemistry. 277 (28): 25400–25407. doi:10.1074/jbc.M110793200. PMID 11950833.
↑ Nishizumi H, Komiyama T, Miyabayashi T, Sakano S, Sakano H (May 2002). "BET, a novel neuronal transmembrane protein with multiple EGF-like motifs". Neuroreport. 13 (6): 909–915. doi:10.1097/00001756-200205070-00035. PMID 11997712. S2CID 8325151.
↑ "Entrez Gene: DNER delta/notch-like EGF repeat containing".

Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Ramachandran P, Boontheung P, Xie Y, Sondej M, Wong DT, Loo JA (June 2006). "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry". Journal of Proteome Research. 5 (6): 1493–1503. doi:10.1021/pr050492k. PMID 16740002.

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