dGTPase
The enzyme dGTPase (EC 3.1.5.1)[1][2] catalyzes the reaction
- dGTP + H2O deoxyguanosine + triphosphate
This enzyme belongs to the family of hydrolases, specifically those acting on triphosphoric monoester bonds. The systematic name is dGTP triphosphohydrolase. Other names in common use include deoxy-GTPase, deoxyguanosine 5-triphosphate triphosphohydrolase, deoxyguanosine triphosphatase, and deoxyguanosine triphosphate triphosphohydrolase. This enzyme participates in purine metabolism.
Structural studies
[edit]As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1HA3, PDB: 2C77, PDB: 2C78, and PDB: 2DQB.
References
[edit]- ↑ Kornberg SR, Lehman IR, Bessman MJ, Simms ES, Kornberg A (1958). "Enzymatic cleavage of deoxyguanosine triphosphate to deoxyguanosine and tripolyphosphate". J. Biol. Chem. 233 (1): 159–62. doi:10.1016/S0021-9258(19)68047-6. PMID 13563461.
- ↑ Seto D, Bhatnagar SK, Bessman MJ (1988). "The purification and properties of deoxyguanosine triphosphate triphosphohydrolase from E. coli". J. Biol. Chem. 263 (3): 1494–99. doi:10.1016/S0021-9258(19)57330-6. PMID 2826481.
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