// Workers AI · dad joke modeWhat did Cychlorphine say to its friend? You're a cyclical friend.
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| ECHA InfoCard | 100.006.468 |
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| Formula | C23H25ClN4O |
| Molar mass | 408.93 g·mol−1 |
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Cychlorphine (N-Propionitrile chlorphine) is a synthetic opioid chemical compound which has been sold as a designer drug, reported in five European countries since 2024, and in the USA.[1] It has been found in Canada as of September 2025.[2] It is similar in chemical structure to known opioid agonists such as brorphine and spirochlorphine, and is claimed to be an opioid with similar or slightly higher potency than fentanyl, but no pharmacological data for cychlorphine have been published.[3][4][5] It is not a structural analog of morphine, despite the similar name. Instead, it is an orphine.[6] Furthermore, it has been detected as the sole active opioid in fake pharmaceutical opioid preparations that are supposed to contain hydromorphone or oxycodone, further increasing the risk of accidental overdoses.[2]
At least 5 people died from cychlorphine overdoses in England in 2025.[7] Another death was reported in San Francisco, California, in April 2026.[8] According to Dr. Darinka Mileusnic-Polchan, the chief medical officer of Knox and Anderson counties, Tennessee, there have been more than 50 fatal cychlorphine overdoses in the greater Knoxville area since October 2025.[9]
It was added to the German NpSG in December 2025.[10] It was proposed for placement on the Schedule 1 list in the USA on 1 July 2026,[11] and has also been recommended for scheduling in individual states such as Kentucky.[12]
See also
[edit]References
[edit]- ↑ Sprague JE, Toms JA, Ratermann CF (December 2025). "Non-fatal opioid overdose associated predominantly with the benzimidazolone, cychlorphine". Clinical Toxicology. Philadelphia, Pa.: 1–2. doi:10.1080/15563650.2025.2594070. PMID 41347459.
- 1 2 Alevato J (November 4, 2025). "A new opioid has been found in Toronto's drug supply and users may not even know it". CBC.ca. Retrieved December 7, 2025.
- ↑ "Chlorphine" (PDF). NPS Discovery — New Drug Monograph. The Center for Forensic Science Research & Education (CSFRE).
- ↑ "European Drug Report 2025 – Full Book" (PDF). European Union Drugs Agency (euda.europa.eu). 6 June 2025.
- ↑ US 3318900, Janssen PA, "Derivatives of benzimidazolinyl piperidine", issued 9 May 1967, assigned to Janssen Pharmaceutica NV
- ↑ "Increase in Fatal Overdoses Linked to Novel Synthetic Opioid N-Propionitrile Chlorphine (Cychlorphine)". The Center for Forensic Science Research & Education. January 30, 2026. Retrieved February 20, 2026.
- ↑ Barradale G (December 5, 2025). "Warning over new opioid 200 times stronger than heroin as three dead within days". The Big Issue. Retrieved December 7, 2025.
- ↑ "Fatal Overdose Involving Novel Synthetic Opioids". SF.gov. April 24, 2026. Retrieved April 26, 2026.
- ↑ "A Medical Examiner Chases Down an Elusive Killer". nytimes.com. May 4, 2026. Retrieved May 4, 2026.
- ↑ "synthetisches Opioid Cychlorphine im Raum Karlsruhe". Drogenportal der Deutschen Aidshilfe (in German). 2025-12-17. Retrieved 2025-12-27.
- ↑ Schedules of Controlled Substances: Temporary Placement of 5,6- Dichloro Brorphine, 5,6-Dichloro Desmethylchlorphine, N-Propionitrile Chlorphine, and Spirochlorphine in Schedule I of the Controlled Substances Act. Department of Justice, Drug Enforcement Administration. 21 CFR Part 1308. Docket No. DEA-1665. 1 July 2026
- ↑ AN ACT relating to cychlorphine. House Bill 750, Kentucky General Assembly