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// Workers AI · dad joke modeWhat did carnosol say to the steak? "You're meat for me.

From Wikipedia, the free encyclopedia
Carnosol
Chemical structure of carnosol
Chemical structure of carnosol
Names
IUPAC name
11,12-Dihydroxy-7β,20-epoxyabieta-8,11,13-trien-20-one
Systematic IUPAC name
(4aR,9S,10aS)-5,6-Dihydroxy-1,1-dimethyl-7-(propan-2-yl)-1,3,4,9,10,10a-hexahydro-2H-9,4a-(epoxymethano)phenanthren-12-one
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1
    Key: XUSYGBPHQBWGAD-PJSUUKDQSA-N
  • InChI=1/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1
    Key: XUSYGBPHQBWGAD-PJSUUKDQBN
  • CC(C)C1=CC2=C(C(=C1O)O)[C@@]34CCCC([C@@H]3C[C@@H]2OC4=O)(C)C
Properties
C20H26O4
Molar mass 330.424 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Carnosol is a phenolic diterpene found in the herbs rosemary (Rosmarinus officinalis)[1] and Mountain desert sage (Salvia pachyphylla).[2]

It has been studied in-vitro for anti-cancer effects in various cancer cell types.[3]

See also

[edit]

References

[edit]
  1. ↑ Ai-Hsiang Lo; Yu-Chih Liang; Shoei-Yn Lin-Shiau; Chi-Tang Ho; Jen-Kun Lin (2002). "Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-κB in mouse macrophages". Carcinogenesis. 23 (6): 983–991. doi:10.1093/carcin/23.6.983. PMID 12082020.
  2. ↑ Ivan C. Guerrero; Lucia S. Andres; Leticia G. Leon; Ruben P. Machin; Jose M. Padron; Javier G. Luis; Jose Delgadillo (2006). "Abietane Diterpenoids from Salvia pachyphylla and S. clevelandii with Cytotoxic Activity against Human Cancer Cell Lines". J. Nat. Prod. 69 (12): 1803–1805. doi:10.1021/np060279i. PMID 17190465.
  3. ↑ Johnson JJ (June 2011). "Carnosol: a promising anti-cancer and anti-inflammatory agent". Cancer Lett. 305 (1): 1–7. doi:10.1016/j.canlet.2011.02.005. PMC 3070765. PMID 21382660.