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The Cas family of proteins are a family of proteins that induce cellular apoptosis and cell proliferation.[5] Apoptosis is a specialized sequence of events that a cell can induce for programmed death. Cas is a 2 terminal protein, a N-terminal and a C-terminal, and there is a positive correlation between the presence of CAS and the degree of cellular proliferation. Along with this correlation, in the absence of the CAS protein in a cell, there is an inhibition of apoptosis Along with being an inducer of apoptosis, CAS also plays a role in being a checkpoint for cell cycle.[5] Without the CAS protein, a cell will not be able to go beyond the G2 phase. It is in the nucleus of the cell, where its exportin function comes into play.
↑"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
12Jiang MC (October 2016). "CAS (CSE1L) signaling pathway in tumor progression and its potential as a biomarker and target for targeted therapy". Tumour Biology. 37 (10): 13077–13090. doi:10.1007/s13277-016-5301-x. PMID27596143. S2CID31420897.
