CRYBG1

CRYBG1
Identifiers
Aliases	CRYBG1, ST4, AIM1, absent in melanoma 1, crystallin beta-gamma domain containing 1
External IDs	OMIM: 601797; MGI: 109544; GeneCards: CRYBG1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3CW3, 2DAD,%%s2DAD
Gene location (Human)
Chr.	Chromosome 6 (human)
End	106,572,017 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	44,024,849 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; oral cavity; ; gums; ; pancreatic ductal cell; ; gingival epithelium; ; mucosa of pharynx; ; placenta; ; vulva; ; palpebral conjunctiva; ; skin of hip;
	Top expressed in
	corneal stroma; ; Ileal epithelium; ; superior surface of tongue; ; esophagus; ; lip; ; skin of back; ; transitional epithelium of urinary bladder; ; skin of external ear; ; lactiferous gland; ; zygote;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	carbohydrate binding; molecular function;
Cellular component	cellular component;
Biological process	biological process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	202
	11630
	ENSG00000112297
	ENSMUSG00000019866
	Q9Y4K1; Q96QW7
	n/a
	NM_001624; NM_001371242
	NM_172393; NM_001368305; NM_001368306
	NP_001615; NP_001358171
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Crystallin beta-gamma domain containing 1 is a protein that in humans is encoded by the CRYBG1 gene (previously AIM1).^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000112297 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019866 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Millikin D, Meese E, Vogelstein B, Witkowski C, Trent J (Nov 1991). "Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma". Cancer Research. 51 (20): 5449–53. PMID 1680551.
↑ Rajini B, Graham C, Wistow G, Sharma Y (Apr 2003). "Stability, homodimerization, and calcium-binding properties of a single, variant betagamma-crystallin domain of the protein absent in melanoma 1 (AIM1)". Biochemistry. 42 (15): 4552–9. doi:10.1021/bi027384l. PMID 12693952.
↑ "Entrez Gene: AIM1 absent in melanoma 1".

External links

Human AIM1 genome location and AIM1 gene details page in the UCSC Genome Browser.
PDBe-KB provides an overview of all the structure information available in the PDB for Human Beta/gamma crystallin domain-containing protein 1 (AIM1)

Ray ME, Su YA, Meltzer PS, Trent JM (1996). "Isolation and characterization of genes associated with chromosome-6 mediated tumor suppression in human malignant melanoma". Oncogene. 12 (12): 2527–33. PMID 8700511.
Ray ME, Wistow G, Su YA, et al. (1997). "AIM1, a novel non-lens member of the betagamma-crystallin superfamily, is associated with the control of tumorigenicity in human malignant melanoma". Proceedings of the National Academy of Sciences of the United States of America. 94 (7): 3229–34. Bibcode:1997PNAS...94.3229R. doi:10.1073/pnas.94.7.3229. PMC 20351. PMID 9096375.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Aravind P, Rajini B, Sharma Y, Sankaranarayanan R (2006). "Crystallization and preliminary X-ray crystallographic investigations on a betagamma-crystallin domain of absent in melanoma 1 (AIM1), a protein from Homo sapiens". Acta Crystallographica Section F. 62 (Pt 3): 282–4. doi:10.1107/S1744309106005380. PMC 2197174. PMID 16511323.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000112297 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019866 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1680551-5] Millikin D, Meese E, Vogelstein B, Witkowski C, Trent J (Nov 1991). "Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma". Cancer Research. 51 (20): 5449–53. PMID 1680551.

[pmid12693952-6] Rajini B, Graham C, Wistow G, Sharma Y (Apr 2003). "Stability, homodimerization, and calcium-binding properties of a single, variant betagamma-crystallin domain of the protein absent in melanoma 1 (AIM1)". Biochemistry. 42 (15): 4552–9. doi:10.1021/bi027384l. PMID 12693952.

[entrez-7] "Entrez Gene: AIM1 absent in melanoma 1".

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CRYBG1

References

External links

Further reading