// Workers AI · dad joke modeWhat did CREG1 say to its date? You're my gene match.

CREG1
Identifiers
Aliases	CREG1, CREG, cellular repressor of E1A stimulated genes 1
External IDs	OMIM: 618055; MGI: 1344382; HomoloGene: 31199; GeneCards: CREG1; OMA:CREG1 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XHN
Gene location (Human) Chr. Chromosome 1 (human) Band 1q24.2 Start 167,529,117 bp End 167,553,805 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 H2.3 Start 165,591,315 bp End 165,602,877 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh hair follicle vulva skin of arm gallbladder parotid gland lower lobe of lung skin of hip gingival epithelium trabecular bone Top expressed in blood stroma of bone marrow left lobe of liver epithelium of stomach fetal liver hematopoietic progenitor cell transitional epithelium of urinary bladder saccule otic placode lacrimal gland tibiofemoral joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription factor binding transcription corepressor activity Cellular component extracellular exosome transcription regulator complex extracellular region extracellular space azurophil granule lumen Biological process regulation of transcription by RNA polymerase II multicellular organism development regulation of growth cell population proliferation regulation of transcription, DNA-templated negative regulation of nucleic acid-templated transcription neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8804 433375 Ensembl ENSG00000143162 ENSMUSG00000040713 UniProt O75629 O88668 RefSeq (mRNA) NM_003851 NM_011804 RefSeq (protein) NP_003842 NP_035934 Location (UCSC) Chr 1: 167.53 – 167.55 Mb Chr 1: 165.59 – 165.6 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Protein CREG1 (Cellular Repressor of E1A-stimulated Genes 1) is a protein that in humans is encoded by the CREG1 gene.

The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation.

External links

• Human CREG1 genome location and CREG1 gene details page in the UCSC Genome Browser.

Further reading

• Veal E, Groisman R, Eisenstein M, Gill G (2000). "The secreted glycoprotein CREG enhances differentiation of NTERA-2 human embryonal carcinoma cells". Oncogene. 19 (17): 2120–8. doi:10.1038/sj.onc.1203529. PMID 10815803.
• Jiang LQ, Wen SJ, Wang HY, Chen LY (2003). "Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system". Hypertens. Res. 25 (4): 647–52. doi:10.1291/hypres.25.647. PMID 12358155.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Di Bacco A, Gill G (2003). "The secreted glycoprotein CREG inhibits cell growth dependent on the mannose-6-phosphate/insulin-like growth factor II receptor". Oncogene. 22 (35): 5436–45. doi:10.1038/sj.onc.1206670. PMID 12934103.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Sacher M, Di Bacco A, Lunin VV, et al. (2006). "The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation". Proc. Natl. Acad. Sci. U.S.A. 102 (51): 18326–31. doi:10.1073/pnas.0505071102. PMC 1317909. PMID 16344469.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.