// Workers AI · dad joke modeWhat did CMAS say to its friend? "Sea" you later.

CMAS
Identifiers
Aliases	CMAS, CSS, cytidine monophosphate N-acetylneuraminic acid synthetase
External IDs	OMIM: 603316; MGI: 1337124; GeneCards: CMAS
Enzyme activity
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	142,721,440 bp
RNA expression pattern
	Top expressed in
	rectum; ; prefrontal cortex; ; left adrenal gland; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; amygdala; ; islet of Langerhans; ; monocyte; ; nucleus accumbens; ; duodenum;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; conjunctival fornix; ; blood; ; submandibular gland; ; left colon; ; facial motor nucleus; ; tibiofemoral joint; ; superior cervical ganglion; ; medial vestibular nucleus; ; dorsal tegmental nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotidyltransferase activity; N-acylneuraminate cytidylyltransferase activity;
Cellular component	membrane; nucleus; nucleoplasm;
Biological process	N-acetylneuraminate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry
	55907
	12764
	n/a
	ENSMUSG00000030282
	Q8NFW8
	Q99KK2
	NM_018686
	NM_009908
	NP_061156
	NP_034038
	Wikidata
View/Edit Human	View/Edit Mouse

N-acylneuraminate cytidylyltransferase is an enzyme that in humans is encoded by the CMAS gene.^[4]^[5]^[6]

Function

The enzyme encoded by this gene catalyzes the activation of Neu5Ac to Cytidine 5-prime-monophosphate N-acetylneuraminic acid (CMP-Neu5Ac), which provides the substrate required for the addition of sialic acid. Sialic acids of cell surface glycoproteins and glycolipids play a pivotal role in the structure and function of animal tissues. The pattern of cell surface sialylation is highly regulated during embryonic development, and changes with stages of differentiation. Studies of a similar murine protein suggest that this protein localizes to the nucleus.^[6]

References

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030282 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (September 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
↑ Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
1 2 "Entrez Gene: CMAS cytidine monophosphate N-acetylneuraminic acid synthetase".

External links

Human CMAS genome location and CMAS gene details page in the UCSC Genome Browser.

Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Münster AK, Eckhardt M, Potvin B, Mühlenhoff M, Stanley P, Gerardy-Schahn R (August 1998). "Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs". Proceedings of the National Academy of Sciences of the United States of America. 95 (16): 9140–5. Bibcode:1998PNAS...95.9140M. doi:10.1073/pnas.95.16.9140. PMC 21305. PMID 9689047.
Angata T, Varki NM, Varki A (October 2001). "A second uniquely human mutation affecting sialic acid biology". The Journal of Biological Chemistry. 276 (43): 40282–7. doi:10.1074/jbc.M105926200. PMID 11546777.
Lawrence SM, Huddleston KA, Tomiya N, Nguyen N, Lee YC, Vann WF, Coleman TA, Betenbaugh MJ (March 2001). "Cloning and expression of human sialic acid pathway genes to generate CMP-sialic acids in insect cells". Glycoconjugate Journal. 18 (3): 205–13. doi:10.1023/A:1012452705349. PMID 11602804. S2CID 21504026.
Munster AK, Weinhold B, Gotza B, Muhlenhoff M, Frosch M, Gerardy-Schahn R (May 2002). "Nuclear localization signal of murine CMP-Neu5Ac synthetase includes residues required for both nuclear targeting and enzymatic activity". The Journal of Biological Chemistry. 277 (22): 19688–96. doi:10.1074/jbc.M201093200. PMID 11893746.
Kutsenko AS, Gizatullin RZ, Al-Amin AN, Wang F, Kvasha SM, Podowski RM, Matushkin YG, Gyanchandani A, Muravenko OV, Levitsky VG, Kolchanov NA, Protopopov AI, Kashuba VI, Kisselev LL, Wasserman W, Wahlestedt C, Zabarovsky ER (July 2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Research. 30 (14): 3163–70. doi:10.1093/nar/gkf428. PMC 135748. PMID 12136098.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information.

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030282 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8889549-4] Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (September 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.

[pmid7566098-5] Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.

[entrez-6] 1 2 "Entrez Gene: CMAS cytidine monophosphate N-acetylneuraminic acid synthetase".

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// Workers AI · dad joke modeWhat did CMAS say to its friend? "Sea" you later.

Function

References

External links

Further reading