// Workers AI · dad joke modeWhat did CLIC3 say to its friend? "Let's click.

CLIC3
Identifiers
Aliases	CLIC3, chloride intracellular channel 3
External IDs	OMIM: 606533; MGI: 1916704; HomoloGene: 3432; GeneCards: CLIC3; OMA:CLIC3 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FY7, 3KJY
Gene location (Human) Chr. Chromosome 9 (human) Band 9q34.3 Start 136,994,608 bp End 136,996,568 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 A3 Start 25,346,850 bp End 25,348,788 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oral cavity right lobe of thyroid gland left lobe of thyroid gland skin of abdomen skin of leg granulocyte mucosa of pharynx right lung gums placenta Top expressed in lip esophagus right lung lobe left lung left lung lobe corneal stroma skin of external ear skin of back skin of abdomen umbilical cord More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding voltage-gated ion channel activity chloride channel activity glutathione transferase activity Cellular component cytoplasm integral component of membrane extracellular exosome membrane nucleus chloride channel complex nuclear body Biological process regulation of ion transmembrane transport chloride transport ion transport signal transduction chloride transmembrane transport glutathione metabolic process transport ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9022 69454 Ensembl ENSG00000169583 ENSMUSG00000015093 UniProt O95833 Q9D7P7 RefSeq (mRNA) NM_004669 NM_027085 RefSeq (protein) NP_004660 NP_081361 Location (UCSC) Chr 9: 136.99 – 137 Mb Chr 2: 25.35 – 25.35 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Chloride intracellular channel protein 3 is a protein that in humans is encoded by the CLIC3 gene. This protein is a chloride channel.

See also

• Chloride channel

Further reading

• Singh H (2010). "Two decades with dimorphic Chloride Intracellular Channels (CLICs)". FEBS Letters. 584 (10): 2112–21. Bibcode:2010FEBSL.584.2112S. doi:10.1016/j.febslet.2010.03.013. PMID 20226783. S2CID 21056278.
• Valenzuela SM, Martin DK, Por SB, et al. (1997). "Molecular cloning and expression of a chloride ion channel of cell nuclei". J. Biol. Chem. 272 (19): 12575–82. doi:10.1074/jbc.272.19.12575. PMID 9139710.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suginta W, Karoulias N, Aitken A, Ashley RH (2001). "Chloride intracellular channel protein CLIC4 (p64H1) binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms". Biochem. J. 359 (Pt 1): 55–64. doi:10.1042/0264-6021:3590055. PMC 1222121. PMID 11563969.
• Money TT, King RG, Wong MH, et al. (2007). "Expression and cellular localisation of chloride intracellular channel 3 in human placenta and fetal membranes". Placenta. 28 (5–6): 429–36. doi:10.1016/j.placenta.2006.08.002. PMID 17027078.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• CLIC3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CLIC3 genome location and CLIC3 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: O95833 (Human Chloride intracellular channel protein 3 (CLIC3)) at the PDBe-KB.