// Workers AI · dad joke modeWhat did CLDN17 gene say? I'm closed in.

CLDN17
Identifiers
Aliases	CLDN17, claudin 17
External IDs	OMIM: 617005; MGI: 2652030; GeneCards: CLDN17
Gene location (Human)
Chr.	Chromosome 21 (human)
End	30,166,805 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	88,303,866 bp
RNA expression pattern
	Top expressed in
	testicle; ; cervix epithelium; ; oral cavity; ; human penis; ; epithelium of esophagus; ; gums; ; vagina; ; body of tongue; ; vulva; ; gingival epithelium;
	Top expressed in
	esophagus; ; embryo; ; ear; ; surface ectoderm; ; nose; ; pharyngeal arch; ; lip; ; stomach; ; zone of skin; ; visual system;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural molecule activity; identical protein binding; chloride channel activity; protein binding;
Cellular component	integral component of membrane; cell junction; plasma membrane; membrane; bicellular tight junction; chloride channel complex;
Biological process	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; ion transport; chloride transport; chloride transmembrane transport; transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	26285
	239931
	ENSG00000156282
	ENSMUSG00000055811
	P56750
	Q8BXA6
	NM_012131
	NM_181490
	NP_036263
	NP_852467
	Wikidata
View/Edit Human	View/Edit Mouse

Claudin-17 is a protein that in humans is encoded by the CLDN17 gene.^[5]^[6] It belongs to the group of claudins; claudins are cell-cell junction proteins that keep that maintains cell- and tissue-barrier function.^[7] It forms anion-selective paracellular channels and is localized mainly in kidney proximal tubules.^[8]^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000156282 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055811 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Katoh M, Katoh M (May 2003). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family". International Journal of Molecular Medicine. 11 (6): 683–689. doi:10.3892/ijmm.11.6.683. PMID 12736707.
↑ "Entrez Gene: CLDN17 claudin 17".
↑ Adil MS, Narayanan SP, Somanath PR (January 2021). "Cell-cell junctions: structure and regulation in physiology and pathology". Tissue Barriers. 9 (1) 1848212. doi:10.1080/21688370.2020.1848212. PMC 7849786. PMID 33300427.
↑ Krug SM, Günzel D, Conrad MP, Rosenthal R, Fromm A, Amasheh S, et al. (2012). "Claudin-17 forms tight junction channels with distinct anion selectivity". Cellular and Molecular Life Sciences. 69 (16): 2765–2778. doi:10.1007/s00018-012-0949-x. PMC 11115135. PMID 22402829. S2CID 18173604.
↑ Adil MS, Parvathagiri V, Verma A, Liu F, Rudraraju M, Narayanan SP, et al. (May 2022). "Claudin-17 Deficiency in Mice Results in Kidney Injury Due to Electrolyte Imbalance and Oxidative Stress". Cells. 11 (11): 1782. doi:10.3390/cells11111782. PMC 9180152. PMID 35681477.

External links

Human CLDN17 genome location and CLDN17 gene details page in the UCSC Genome Browser.

González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Progress in Biophysics and Molecular Biology. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Current Opinion in Cell Biology. 14 (5): 531–536. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nature Reviews. Molecular Cell Biology. 2 (4): 285–293. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.
Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2). Copenhagen, Denmark: 93–98. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307. S2CID 12132159.
Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cellular and Molecular Neurobiology. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMC 11537529. PMID 10690502. S2CID 26473781.
Hu YH, Warnatz HJ, Vanhecke D, Wagner F, Fiebitz A, Thamm S, et al. (June 2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7 (1) 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
Brandner JM, Kief S, Grund C, Rendl M, Houdek P, Kuhn C, et al. (May 2002). "Organization and formation of the tight junction system in human epidermis and cultured keratinocytes". European Journal of Cell Biology. 81 (5): 253–263. doi:10.1078/0171-9335-00244. PMID 12067061.
Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, et al. (2015). "A systems proteomics view of the endogenous human claudin protein family". Journal of Proteome Research. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.

This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000156282 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055811 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Katoh_2003-5] Katoh M, Katoh M (May 2003). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family". International Journal of Molecular Medicine. 11 (6): 683–689. doi:10.3892/ijmm.11.6.683. PMID 12736707.

[entrez-6] "Entrez Gene: CLDN17 claudin 17".

[7] Adil MS, Narayanan SP, Somanath PR (January 2021). "Cell-cell junctions: structure and regulation in physiology and pathology". Tissue Barriers. 9 (1) 1848212. doi:10.1080/21688370.2020.1848212. PMC 7849786. PMID 33300427.

[8] Krug SM, Günzel D, Conrad MP, Rosenthal R, Fromm A, Amasheh S, et al. (2012). "Claudin-17 forms tight junction channels with distinct anion selectivity". Cellular and Molecular Life Sciences. 69 (16): 2765–2778. doi:10.1007/s00018-012-0949-x. PMC 11115135. PMID 22402829. S2CID 18173604.

[9] Adil MS, Parvathagiri V, Verma A, Liu F, Rudraraju M, Narayanan SP, et al. (May 2022). "Claudin-17 Deficiency in Mice Results in Kidney Injury Due to Electrolyte Imbalance and Oxidative Stress". Cells. 11 (11): 1782. doi:10.3390/cells11111782. PMC 9180152. PMID 35681477.

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References

External links

Further reading