// Workers AI · dad joke modeWhat did CIDEB say to its date? Byte-ing to know you.
| CIDEB | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | CIDEB, cell death-inducing DFFA-like effector b, cell death inducing DFFA like effector b | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 604441; MGI: 1270844; GeneCards: CIDEB | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Cell death-inducing DFFA-like effector b, also known as CIDEB, is a human gene.[5][6][7]
In humans, individuals carrying rare loss of function mutations in the CIDEB gene are protected against different aetiologies of liver disease.[8] CIDEB knockout mice have been generated by homolog recombination technique. The CIDE null mice show decreased lipogenesis. The CIDEB knockout mice are resistant to high fat diet induced obesity and liver steatosis. In addition, the CIDEB null mice also have improved insulin sensitivity and enhanced hepatic fatty acid oxidation and whole body metabolism.[9] CIDEB plays a key role in determining lipid droplet size: overexpression of CIDEB in vitro results in fat accumulation by inducing larger lipid droplets, while CIDEB knock-out experiments results in accumulation of smaller lipid droplets.[10][8]
References
[edit]- 1 2 3 ENSG00000285199 GRCh38: Ensembl release 89: ENSG00000136305, ENSG00000285199 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022219 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Entrez Gene: CIDEB cell death-inducing DFFA-like effector b".
- ↑ Ye J, Li JZ, Liu Y, Li X, Yang T, Ma X, et al. (February 2009). "Cideb, an ER- and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B". Cell Metabolism. 9 (2): 177–190. doi:10.1016/j.cmet.2008.12.013. PMID 19187774.
- ↑ Li JZ, Lei Y, Wang Y, Zhang Y, Ye J, Xia X, et al. (May 2010). "Control of cholesterol biosynthesis, uptake and storage in hepatocytes by Cideb". Biochimica et Biophysica Acta. 1801 (5): 577–586. doi:10.1016/j.bbalip.2010.01.012. PMID 20123130.
- 1 2 Verweij N, Haas ME, Nielsen JB, Sosina OA, Kim M, Akbari P, et al. (July 2022). "Germline Mutations in CIDEB and Protection against Liver Disease". The New England Journal of Medicine. 387 (4): 332–344. doi:10.1056/NEJMoa2117872. PMID 35939579. S2CID 251143047.
- ↑ Li JZ, Ye J, Xue B, Qi J, Zhang J, Zhou Z, et al. (October 2007). "Cideb regulates diet-induced obesity, liver steatosis, and insulin sensitivity by controlling lipogenesis and fatty acid oxidation". Diabetes. 56 (10): 2523–2532. doi:10.2337/db07-0040. PMID 17646209.
- ↑ Xu W, Wu L, Yu M, Chen FJ, Arshad M, Xia X, et al. (February 2016). "Differential Roles of Cell Death-inducing DNA Fragmentation Factor-α-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes". The Journal of Biological Chemistry. 291 (9): 4282–4293. doi:10.1074/jbc.M115.701094. PMC 4813457. PMID 26733203.
Further reading
[edit]- Inohara N, Koseki T, Chen S, Wu X, Núñez G (May 1998). "CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor". The EMBO Journal. 17 (9): 2526–2533. doi:10.1093/emboj/17.9.2526. PMC 1170594. PMID 9564035.
- Lugovskoy AA, Zhou P, Chou JJ, McCarty JS, Li P, Wagner G (December 1999). "Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis". Cell. 99 (7): 747–755. doi:10.1016/S0092-8674(00)81672-4. PMID 10619428.
- Chen Z, Guo K, Toh SY, Zhou Z, Li P (July 2000). "Mitochondria localization and dimerization are required for CIDE-B to induce apoptosis". The Journal of Biological Chemistry. 275 (30): 22619–22622. doi:10.1074/jbc.C000207200. PMID 10837461.
- Liang L, Zhao M, Xu Z, Yokoyama KK, Li T (February 2003). "Molecular cloning and characterization of CIDE-3, a novel member of the cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector family". The Biochemical Journal. 370 (Pt 1): 195–203. doi:10.1042/BJ20020656. PMC 1223158. PMID 12429024.
- Erdtmann L, Franck N, Lerat H, Le Seyec J, Gilot D, Cannie I, et al. (May 2003). "The hepatitis C virus NS2 protein is an inhibitor of CIDE-B-induced apoptosis". The Journal of Biological Chemistry. 278 (20): 18256–18264. doi:10.1074/jbc.M209732200. PMID 12595532.
- Da L, Li D, Yokoyama KK, Li T, Zhao M (February 2006). "Dual promoters control the cell-specific expression of the human cell death-inducing DFF45-like effector B gene". The Biochemical Journal. 393 (Pt 3): 779–788. doi:10.1042/BJ20051027. PMC 1360731. PMID 16248853.
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