// Workers AI · dad joke modeWhat did CHSY1 say to its date? "You synthesize a great couple

CHSY1
Identifiers
Aliases	CHSY1, CHSY, CSS1, ChSy-1, TPBS, chondroitin sulfate synthase 1
External IDs	OMIM: 608183; MGI: 2681120; HomoloGene: 8950; GeneCards: CHSY1; OMA:CHSY1 - orthologs
Enzyme activity
Gene location (Human)
Chr.	Chromosome 15 (human)
End	101,252,048 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	65,823,546 bp
RNA expression pattern
	Top expressed in
	tibia; ; decidua; ; visceral pleura; ; endothelial cell; ; Epithelium of choroid plexus; ; vena cava; ; hair follicle; ; cartilage tissue; ; gingival epithelium; ; synovial joint;
	Top expressed in
	hand; ; secondary oocyte; ; Gonadal ridge; ; primary oocyte; ; endocardial cushion; ; semi-lunar valve; ; renal corpuscle; ; aortic valve; ; calvaria; ; otolith organ;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; transferase activity; acetylgalactosaminyltransferase activity; glycosyltransferase activity; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;
Cellular component	extracellular region; integral component of membrane; Golgi apparatus; Golgi membrane; Golgi cisterna membrane; membrane;
Biological process	proximal/distal pattern formation; bone morphogenesis; cartilage development; chondrocyte development; negative regulation of ossification; sulfation; positive regulation of smoothened signaling pathway; response to nutrient levels; chondroitin sulfate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	22856
	269941
	ENSG00000131873
	ENSMUSG00000032640
	Q86X52
	Q6ZQ11
	NM_014918
	NM_001081163
	NP_055733
	NP_001074632
	Wikidata
View/Edit Human	View/Edit Mouse

Chondroitin sulfate synthase 1 is an enzyme that in humans is encoded by the CHSY1 gene.^[5]^[6]

CHSY1 synthesizes chondroitin sulfate, a glycosaminoglycan expressed on the surface of most cells and in extracellular matrices. Glycosaminoglycan chains are covalently linked to a wide range of core protein families and regulate many biologic processes, including cell proliferation and recognition, extracellular matrix deposition, and morphogenesis.^[7]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000131873 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032640 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kitagawa H, Uyama T, Sugahara K (Oct 2001). "Molecular cloning and expression of a human chondroitin synthase". J Biol Chem. 276 (42): 38721–6. doi:10.1074/jbc.M106871200. PMID 11514575.
1 2 "Entrez Gene: CHSY1 carbohydrate (chondroitin) synthase 1".
↑ supplied by OMIM

External links

Human CHSY1 genome location and CHSY1 gene details page in the UCSC Genome Browser.

Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Yada T, Sato T, Kaseyama H, et al. (2003). "Chondroitin sulfate synthase-3. Molecular cloning and characterization". J. Biol. Chem. 278 (41): 39711–25. doi:10.1074/jbc.M304421200. PMID 12907687.
Kitagawa H, Izumikawa T, Uyama T, Sugahara K (2003). "Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization". J. Biol. Chem. 278 (26): 23666–71. doi:10.1074/jbc.M302493200. PMID 12716890.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000131873 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032640 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11514575-5] Kitagawa H, Uyama T, Sugahara K (Oct 2001). "Molecular cloning and expression of a human chondroitin synthase". J Biol Chem. 276 (42): 38721–6. doi:10.1074/jbc.M106871200. PMID 11514575.

[entrez-6] 1 2 "Entrez Gene: CHSY1 carbohydrate (chondroitin) synthase 1".

[7] supplied by OMIM

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// Workers AI · dad joke modeWhat did CHSY1 say to its date? "You synthesize a great couple

References

External links

Further reading