CDCA5

CDCA5
Identifiers
Aliases	CDCA5, SORORIN, cell division cycle associated 5
External IDs	OMIM: 609374; MGI: 1915099; GeneCards: CDCA5
Gene location (Human)
Chr.	Chromosome 11 (human)
End	65,084,164 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	6,141,807 bp
RNA expression pattern
	Top expressed in
	gonad; ; ventricular zone; ; right testis; ; left testis; ; ganglionic eminence; ; mucosa of transverse colon; ; testicle; ; bone marrow; ; secondary oocyte; ; appendix;
	Top expressed in
	primary oocyte; ; zygote; ; secondary oocyte; ; primitive streak; ; fetal liver hematopoietic progenitor cell; ; internal carotid artery; ; Paneth cell; ; otic placode; ; somite; ; external carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	chromatin binding; protein binding; protein-containing complex binding;
Cellular component	cytoplasm; cytosol; cohesin complex; chromosome; nucleoplasm; chromatin; chromosome, centromeric region; nucleus;
Biological process	mitotic chromosome condensation; positive regulation of exit from mitosis; regulation of cohesin loading; cell division; mitotic sister chromatid cohesion; double-strand break repair; cell cycle; mitotic metaphase plate congression; mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	113130
	67849
	ENSG00000146670
	ENSMUSG00000024791
	Q96FF9
	Q9CPY3
	NM_080668
	NM_026410
	NP_542399
	NP_080686
	Wikidata
View/Edit Human	View/Edit Mouse

Sororin is a protein that in humans is encoded by the CDCA5 gene.^[5]^[6]^[7]

Function

Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.^[8]

Clinical significance

Transactivation of Sororin and its phosphorylation at Ser209 by ERK play an important role in lung cancer proliferation.^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000146670 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024791 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Walker MG (May 2001). "Drug target discovery by gene expression analysis: cell cycle genes". Current Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.
↑ Rankin S, Ayad NG, Kirschner MW (April 2005). "Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates". Molecular Cell. 18 (2): 185–200. doi:10.1016/j.molcel.2005.03.017. PMID 15837422.
↑ "Entrez Gene: CDCA5 cell division cycle associated 5".
↑ Schmitz J, Watrin E, Lénárt P, Mechtler K, Peters JM (April 2007). "Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase". Current Biology. 17 (7): 630–636. Bibcode:2007CBio...17..630S. doi:10.1016/j.cub.2007.02.029. hdl:21.11116/0000-0002-101C-D. PMID 17349791. S2CID 11988060.
↑ Nguyen MH, Koinuma J, Ueda K, Ito T, Tsuchiya E, Nakamura Y, et al. (July 2010). "Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis". Cancer Research. 70 (13): 5337–5347. doi:10.1158/0008-5472.CAN-09-4372. PMID 20551060.

External links

Human CDCA5 genome location and CDCA5 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000146670 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024791 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Walker_2001-5] Walker MG (May 2001). "Drug target discovery by gene expression analysis: cell cycle genes". Current Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.

[Rankin_2005-6] Rankin S, Ayad NG, Kirschner MW (April 2005). "Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates". Molecular Cell. 18 (2): 185–200. doi:10.1016/j.molcel.2005.03.017. PMID 15837422.

[entrez-7] "Entrez Gene: CDCA5 cell division cycle associated 5".

[Schmitz-2007-8] Schmitz J, Watrin E, Lénárt P, Mechtler K, Peters JM (April 2007). "Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase". Current Biology. 17 (7): 630–636. Bibcode:2007CBio...17..630S. doi:10.1016/j.cub.2007.02.029. hdl:21.11116/0000-0002-101C-D. PMID 17349791. S2CID 11988060.

[Nguyen-2010-9] Nguyen MH, Koinuma J, Ueda K, Ito T, Tsuchiya E, Nakamura Y, et al. (July 2010). "Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis". Cancer Research. 70 (13): 5337–5347. doi:10.1158/0008-5472.CAN-09-4372. PMID 20551060.

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CDCA5

Function

Clinical significance

References

Further reading

External links