CCT6A

CCT6A
Identifiers
Aliases	CCT6A, CCT-zeta, CCT-zeta-1, CCT6, Cctz, HTR3, MoDP-2, TCP-1-zeta, TCP20, TCPZ, TTCP20, chaperonin containing TCP1 subunit 6A
External IDs	OMIM: 104613; MGI: 107943; HomoloGene: 1336; GeneCards: CCT6A; OMA:CCT6A - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7p11.2 Start 56,051,685 bp End 56,063,989 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 G1.3 Start 129,864,062 bp End 129,875,212 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ganglionic eminence ventricular zone body of pancreas skin of abdomen superior surface of tongue mucosa of transverse colon skin of leg islet of Langerhans stromal cell of endometrium Top expressed in primitive streak superior cervical ganglion mandibular prominence maxillary prominence abdominal wall migratory enteric neural crest cell Gonadal ridge trigeminal ganglion human fetus somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein folding chaperone activity nucleotide binding WD40-repeat domain binding protein binding ATP binding unfolded protein binding RNA binding Cellular component chaperonin-containing T-complex microtubule extracellular exosome extracellular matrix cytoplasm cytosol Biological process positive regulation of establishment of protein localization to telomere protein stabilization positive regulation of telomere maintenance via telomerase protein folding positive regulation of protein localization to Cajal body positive regulation of telomerase RNA localization to Cajal body 'de novo' protein folding chaperone-mediated protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 908 12466 Ensembl ENSG00000146731 ENSMUSG00000029447 UniProt P40227 P80317 RefSeq (mRNA) NM_001762 NM_001009186 NM_009838 RefSeq (protein) NP_001009186 NP_001753 NP_033968 Location (UCSC) Chr 7: 56.05 – 56.06 Mb Chr 5: 129.86 – 129.88 Mb PubMed search
Wikidata
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T-complex protein 1 subunit zeta is a protein that in humans is encoded by the CCT6A gene.

Function

This gene encodes a molecular chaperone that is member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.

Interactions

CCT6A has been shown to interact with PPP4C.

External links

• Human CCT6A genome location and CCT6A gene details page in the UCSC Genome Browser.

Further reading

• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
• Kubota H, Hynes G, Carne A, Ashworth A, Willison K (1994). "Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin". Curr. Biol. 4 (2): 89–99. Bibcode:1994CBio....4...89K. doi:10.1016/S0960-9822(94)00024-2. PMID 7953530. S2CID 31300131.
• Schwartz GJ, Kittelberger AM, Segel GB (2000). "Cloning of rabbit Cct6 and the distribution of the Cct complex in mammalian tissues". Exp. Nephrol. 8 (3): 152–60. doi:10.1159/000020663. PMID 10810232. S2CID 28781053.
• Yokota S, Yanagi H, Yura T, Kubota H (2001). "Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle". Eur. J. Biochem. 268 (17): 4664–73. doi:10.1046/j.1432-1327.2001.02393.x. PMID 11532003.
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R (2004). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". J. Biol. Chem. 278 (51): 51901–10. doi:10.1074/jbc.M309655200. PMID 14532270.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Higo M, Uzawa K, Kouzu Y, Bukawa H, Nimura Y, Seki N, Tanzawa H (2005). "Identification of candidate radioresistant genes in human squamous cell carcinoma cells through gene expression analysis using DNA microarrays". Oncol. Rep. 14 (5): 1293–8. doi:10.3892/or.14.5.1293. PMID 16211299.
• Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.