// Workers AI · dad joke modeWhat did CADPS2 say to its date? You cad, PS2 be mine.

CADPS2
Identifiers
Aliases	CADPS2, CAPS2, calcium dependent secretion activator 2
External IDs	OMIM: 609978; MGI: 2443963; GeneCards: CADPS2
Gene location (Human)
Chr.	Chromosome 7 (human)
End	122,886,759 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	23,839,420 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; parotid gland; ; Brodmann area 23; ; primary visual cortex; ; endothelial cell; ; middle temporal gyrus; ; gastric mucosa; ; Brodmann area 46;
	Top expressed in
	habenula; ; gray matter layer of cerebellum; ; lobe of cerebellum; ; suprachiasmatic nucleus; ; cerebellar vermis; ; granular layer; ; Region I of hippocampus proper; ; substantia nigra; ; subiculum; ; olfactory system;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; lipid binding;
Cellular component	cell junction; postsynaptic membrane; cytoplasmic vesicle; synapse; cytoplasmic vesicle membrane; presynaptic membrane; intracellular membrane-bounded organelle; membrane; nucleoplasm; parallel fiber to Purkinje cell synapse; presynapse; glutamatergic synapse;
Biological process	exocytosis; protein transport; cellular response to starvation; positive regulation of exocytosis; synaptic vesicle priming; dense core granule exocytosis; synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	93664
	320405
	ENSG00000081803
	ENSMUSG00000017978
	Q86UW7
	Q8BYR5
NM_001009571; NM_001167940; NM_017954; NM_001363389; NM_001363390;
	NM_001363391; NM_001363392; NM_001363393; NM_001363394; NM_001363395; NM_001363396; NM_001363397; NM_001363398; NM_001363399; NM_001363400
NM_001252105; NM_001252106; NM_001252107; NM_001252108; NM_001252109;
	NM_001252110; NM_153163
NP_001009571; NP_001161412; NP_060424; NP_001350318; NP_001350319;
	NP_001350320; NP_001350321; NP_001350322; NP_001350323; NP_001350324; NP_001350325; NP_001350326; NP_001350327; NP_001350328; NP_001350329
NP_001239034; NP_001239035; NP_001239036; NP_001239037; NP_001239038;
	NP_001239039; NP_694803; NP_001390537; NP_001390559
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium-dependent secretion activator 2 is a protein that in humans is encoded by the CADPS2 gene.^[5]

Function

This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium-binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells.^[5]

Interactions

This gene interacts with brain-derived neurotrophic factor.

Clinical significance

Cadps2 has been linked to autism^[6] and is in the 7q autism susceptibility locus (AUTS1). However, the finding of aberrant CADPS2 splicing was not found to be significant in another study.^[7]

A knockout mouse model was found to have autistic-like characteristics.^[6]

CADPS2 has been linked to human and mouse brain structure in two large genomic studies.^[8]^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000081803 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000017978 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: CADPS2 Ca2+-dependent activator protein for secretion 2". National Center for Biotechnology Information.
1 2 Sadakata T, Washida M, Iwayama Y, Shoji S, Sato Y, Ohkura T, et al. (April 2007). "Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients". The Journal of Clinical Investigation. 117 (4): 931–943. doi:10.1172/JCI29031. PMC 1821065. PMID 17380209.
↑ Eran A, Graham KR, Vatalaro K, McCarthy J, Collins C, Peters H, et al. (April 2009). "Comment on "Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients"". The Journal of Clinical Investigation. 119 (4): 679–80, author reply 680–1. doi:10.1172/JCI38620. PMC 2662571. PMID 19339759.
↑ French L, Pavlidis P (January 2011). "Relationships between gene expression and brain wiring in the adult rodent brain". PLOS Computational Biology. 7 (1) e1001049. Bibcode:2011PLSCB...7E1049F. doi:10.1371/journal.pcbi.1001049. PMC 3017102. PMID 21253556.
↑ Stein JL, Hua X, Lee S, Ho AJ, Leow AD, Toga AW, et al. (November 2010). "Voxelwise genome-wide association study (vGWAS)". NeuroImage. 53 (3): 1160–1174. doi:10.1016/j.neuroimage.2010.02.032. PMC 2900429. PMID 20171287.

External links

Human CADPS2 genome location and CADPS2 gene details page in the UCSC Genome Browser.

Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (August 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (4): 273–281. doi:10.1093/dnares/7.4.271. PMID 10997877.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–1784. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Cisternas FA, Vincent JB, Scherer SW, Ray PN (2003). "Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family". Genomics. 81 (3): 279–291. doi:10.1016/S0888-7543(02)00040-X. PMID 12659812.
Speidel D, Varoqueaux F, Enk C, Nojiri M, Grishanin RN, Martin TF, et al. (December 2003). "A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function". The Journal of Biological Chemistry. 278 (52): 52802–52809. doi:10.1074/jbc.M304727200. PMID 14530279.
Binda AV, Kabbani N, Levenson R (2005). "Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS)". Biochemical Pharmacology. 69 (10): 1451–1461. doi:10.1016/j.bcp.2005.02.015. PMID 15857609.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000081803 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000017978 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: CADPS2 Ca2+-dependent activator protein for secretion 2". National Center for Biotechnology Information.

[sadakata-6] 1 2 Sadakata T, Washida M, Iwayama Y, Shoji S, Sato Y, Ohkura T, et al. (April 2007). "Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients". The Journal of Clinical Investigation. 117 (4): 931–943. doi:10.1172/JCI29031. PMC 1821065. PMID 17380209.

[7] Eran A, Graham KR, Vatalaro K, McCarthy J, Collins C, Peters H, et al. (April 2009). "Comment on "Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients"". The Journal of Clinical Investigation. 119 (4): 679–80, author reply 680–1. doi:10.1172/JCI38620. PMC 2662571. PMID 19339759.

[8] French L, Pavlidis P (January 2011). "Relationships between gene expression and brain wiring in the adult rodent brain". PLOS Computational Biology. 7 (1) e1001049. Bibcode:2011PLSCB...7E1049F. doi:10.1371/journal.pcbi.1001049. PMC 3017102. PMID 21253556.

[9] Stein JL, Hua X, Lee S, Ho AJ, Leow AD, Toga AW, et al. (November 2010). "Voxelwise genome-wide association study (vGWAS)". NeuroImage. 53 (3): 1160–1174. doi:10.1016/j.neuroimage.2010.02.032. PMC 2900429. PMID 20171287.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

This page was redesigned at the edge.

A page that knows where it met you.