// Workers AI · dad joke modeDoes C1QTNF4 have friends? It bonds well.

C1QTNF4
Identifiers
Aliases	C1QTNF4, CTRP4, ZACRP4, C1q and tumor necrosis factor related protein 4, C1q and TNF related 4
External IDs	OMIM: 614911; MGI: 1914695; HomoloGene: 12134; GeneCards: C1QTNF4; OMA:C1QTNF4 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p11.2 Start 47,589,667 bp End 47,594,411 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 E1 Start 90,716,204 bp End 90,720,869 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in primary visual cortex superior frontal gyrus nucleus accumbens putamen caudate nucleus Brodmann area 9 right frontal lobe right hemisphere of cerebellum anterior cingulate cortex temporal lobe Top expressed in striatum of neuraxis superior frontal gyrus primary visual cortex olfactory bulb hippocampus proper spermatid cerebellar cortex spermatocyte testicle neural tube More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity molecular function Cellular component extracellular region extracellular space Biological process regulation of signaling receptor activity positive regulation of interleukin-6 production positive regulation of interleukin-6-mediated signaling pathway positive regulation of NIK/NF-kappaB signaling signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114900 67445 Ensembl ENSG00000172247 ENSG00000284838 ENSMUSG00000040794 UniProt Q9BXJ3 Q8R066 RefSeq (mRNA) NM_031909 NM_026161 RefSeq (protein) NP_114115 NP_080437 Location (UCSC) Chr 11: 47.59 – 47.59 Mb Chr 2: 90.72 – 90.72 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

C1q and tumor necrosis factor related protein 4 is a protein that in humans is encoded by the C1QTNF4 gene (also called CTRP4). C1QTNF4 is a secreted protein that increases cytokine production and signaling effectiveness.

Further reading

• Li Q, Wang L, Tan W, Peng Z, Luo Y, Zhang Y, Zhang G, Na D, Jin P, Shi T, Ma D, Wang L (2011). "Identification of C1qTNF-related protein 4 as a potential cytokine that stimulates the STAT3 and NF-κB pathways and promotes cell survival in human cancer cells". Cancer Lett. 308 (2): 203–14. doi:10.1016/j.canlet.2011.05.005. PMID 21658842.