IHCH-6122

IHCH-6122
Clinical data
Other names	IHCH6122
Drug class	Serotonin 5-HT2A receptor agonist; Serotonin 5-HT2C receptor agonist; Serotonin 5-HT2B receptor antagonist
ATC code	None;
Identifiers
	IUPAC name 3-piperazin-1-yl-5,6,7,8-tetrahydroisoquinoline;
PubChem CID	176915195;
ChemSpider	73044701;
Chemical and physical data
Formula	C13H19N3
Molar mass	217.316 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CCC2=CN=C(C=C2C1)N3CCNCC3;
	InChI InChI=1S/C13H19N3/c1-2-4-12-10-15-13(9-11(12)3-1)16-7-5-14-6-8-16/h9-10,14H,1-8H2; Key:IPQHEOUVJXLYMR-UHFFFAOYSA-N;

IHCH-6122 is a serotonergic drug of the arylpiperazine family, related to older compounds such as quipazine. It acts as an agonist at the 5-HT_2A and 5-HT_2C receptors but is an antagonist at 5-HT_2B receptors, a profile which is hoped to eliminate the issues with cardiac valvulopathies associated with related compounds that act as agonists of the 5-HT_2B receptor. In animal studies, IHCH-6122 produced a head-twitch response and antidepressant-like effects.^[1]^[2]

References

↑ Li H, Tang L, Zhang J, Meng B, Cao D, Chen Y, et al. (17 September 2026). "Structure-based design of subtype-selective psychedelic analogs". Nature Communications. 17 (1) 9874. doi:10.1038/s41467-026-77658-y. PMC 13586271. PMID 42754591.
↑ WO application 2025168125, Cheng JC, Wang SC, Zhang JC, Tang LC, "Serotonin 5-HT2A Receptor Agonist, Preparation Method Therefor, and Use Thereof", published 2025-08-14, assigned to Univ Shanghai Technology [Cn] and Center for Excellence in Molecular Cell Science Chinese Acad of Sciences [Cn]

[1] Li H, Tang L, Zhang J, Meng B, Cao D, Chen Y, et al. (17 September 2026). "Structure-based design of subtype-selective psychedelic analogs". Nature Communications. 17 (1) 9874. doi:10.1038/s41467-026-77658-y. PMC 13586271. PMID 42754591.

[2] WO application 2025168125, Cheng JC, Wang SC, Zhang JC, Tang LC, "Serotonin 5-HT2A Receptor Agonist, Preparation Method Therefor, and Use Thereof", published 2025-08-14, assigned to Univ Shanghai Technology [Cn] and Center for Excellence in Molecular Cell Science Chinese Acad of Sciences [Cn]

[1]

[2]

v t e Arylpiperazines
Phenylpiperazines	1-Phenylpiperazine (1-PP; PP) 3,4-CFP 2C-B-PP Acaprazine Antrafenine Aripiprazole Batoprazine Bifeprunox BRL-15,572 Ciprofloxacin Dapiprazole DCPP DMPP Diphenylpiperazine Dropropizine EGIS-7625 EGIS-12,233 Elopiprazole Eltoprazine Enpiprazole Ensaculin Etoperidone Flesinoxan Fluanisone Flibanserin Fluprazine Itraconazole Ketoconazole Levodropropizine Lorpiprazole mCPP Mefway MeOPP Mepiprazole Naftopidil Naluzotan Nefazodone Niaprazine Oxypertine Pardoprunox pCPP pFPP Posaconazole S-14,506 S-14,671 S-15,535 SB-258,585 SB-271,046 SB-357,134 SB-399,885 Sonepiprazole TFMPP Tolpiprazole Trazodone Urapidil Vesnarinone Vilazodone Vortioxetine WAY-100,135 WAY-100,635
Benzylpiperazines	2C-B-BZP 3-Methylbenzylpiperazine Befuraline Bifeprunox Buclizine BZP Chlorbenzoxamine DBZP EGIS-7625 Fipexide Imatinib MBZP MDBZP Meclozine Methoxypiperamide NSI-189 Piberaline Piribedil RN-1747 Sunifiram Trimetazidine Vesnarinone
Naphthylpiperazines	1-Naphthylpiperazine (1-NP) 2-Naphthylpiperazine (2-NP; 1-deazaquipazine) CSP-2503 F-11,461 S-14,506 S-14671
Quinolinylpiperazines	FPPQ 6-Nitroquipazine Isoquipazine Quipazine VCU-1021 (3-methoxyquipazine)
Diphenylalkylpiperazines	AD-1211 Almitrine Amperozide BRL-15,572 Buclizine BW373U86 Cetirizine Chlorbenzoxamine Chlorcyclizine Cinnarizine Clocinizine Cyclizine DBL-583 Diphenpipenol Diphenylmethylpiperazine Dotarizine DPI-221 DPI-287 DPI-3290 GBR-12,783 GBR-12,935 GBR-13,069 GBR-13,098 GBR-13,119 Hydroxyzine JJC8-088 Lidoflazine Manidipine Meclozine MT-45 Oxatomide SNC-80 Vanoxerine
Pyrimidinylpiperazines	Buspirone Dasatinib Eptapirone Gepirone Ipsapirone Piribedil Pyrimidinylpiperazine Revospirone Tandospirone Tirilazad Trimazosin Umespirone Zalospirone
Pyridinylpiperazines	Atevirdine Azaperone Delavirdine Mirtazapine ORG-12962 Pyridinylpiperazine
Benzo(iso)thiazolyl piperazines	Lurasidone Perospirone Revospirone Tiospirone Ziprasidone
Tricyclic-linked piperazines	Amoxapine Clopenthixol Clorotepine Clozapine Cyanothepin Doclothepin Docloxythepin Flupentixol Fluphenazine Isofloxythepin Loxapine Meperathiepin Metitepine Octomethothepin Olanzapine Opipramol Oxyclothepin Oxyprothepin Peradithiepin Perathiepin Perazine Perphenazine Pirenzepine Prochlorperazine Thiethylperazine Thiothixene Trifluoperazine Trifluthepin Zuclopenthixol
Others/uncategorized	AP-238 Azimilide Bucinnazine Cinepazet Cinepazic acid Cinepazide CPD-1 Cyclohexylpiperazine Hexocyclium Indinavir JNJ-7777120 Lodenafil MK-212 Mirodenafil PB-28 Ranolazine SA-4503 Sildenafil Tadalafil Vardenafil VCU-1012 VUF-6002 WY-46824 Zipeprol ZINC000443438219

This page was redesigned at the edge.

A page that knows where it met you.

IHCH-6122

See also

References