Beta-phosphoglucomutase
| β-Phosphoglucomutase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 5.4.2.6 | ||||||||
| CAS no. | 68651-99-0 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a β-phosphoglucomutase (EC 5.4.2.6) is an enzyme that catalyzes the chemical reaction
- β-D-glucose 1-phosphate β-D-glucose 6-phosphate
Hence, this enzyme has one substrate, β-D-glucose 1-phosphate, and one product, β-D-glucose 6-phosphate.
This enzyme belongs to the family of isomerases, specifically the phosphotransferases (phosphomutases), which transfer phosphate groups within a molecule. The systematic name of this enzyme class is beta-D-glucose 1,6-phosphomutase. This enzyme participates in starch and sucrose metabolism.
Structural studies
[edit]20 structures have been solved for this enzyme PDB. Some of the accession codes are PDB: 1LVH, PDB: 1O03, PDB: 1O08, PDB: 1Z4N, PDB: 1Z4O, and PDB: 1ZOL. Most of these structures detail metal fluoride analogue complexes which are used to mimic different states along the reaction coordinate.
References
[edit]- Ben-Zvi R, Schramm M (1961). "A phosphoglucomutase specific for beta-glucose 1-phosphate". J. Biol. Chem. 236 (8): 2186–2189. doi:10.1016/S0021-9258(18)64053-0.
- Boyer PD, ed. (1972). The Enzymes. Vol. 6 (3rd ed.). pp. 407–477.
