// Workers AI · dad joke modeWhat did bone morphogenetic protein 10 say? "I've got a growth on my mind.

BMP10
Identifiers
Aliases	BMP10, entrez:27302, bone morphogenetic protein 10
External IDs	OMIM: 608748; MGI: 1338820; HomoloGene: 7644; GeneCards: BMP10; OMA:BMP10 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p13.3 Start 68,860,909 bp End 68,871,397 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 D1 Start 87,405,976 bp End 87,414,659 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cardiac muscle tissue of right atrium right auricle of heart right lobe of liver tibialis anterior muscle mucosa of ileum left ventricle gastric mucosa placenta gastrocnemius muscle blood Top expressed in atrium atrioventricular valve primordial ventricle bulbus cordis myocardium of atrium endocardial cushion cardiac muscle tissue of atrium CA3 field perirhinal cortex ventricle of the heart More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity receptor serine/threonine kinase binding hormone activity telethonin binding protein binding transforming growth factor beta receptor binding growth factor activity Cellular component cytoplasm extracellular region cell surface Z discdkac extracellular space Biological process regulation of apoptotic process pathway-restricted SMAD protein phosphorylation regulation of MAPK cascade heart trabecula formation SMAD protein signal transduction negative regulation of cardiac muscle hypertrophy adult heart development positive regulation of pathway-restricted SMAD protein phosphorylation positive regulation of sarcomere organization positive regulation of cell proliferation involved in heart morphogenesis cardiac muscle cell proliferation positive regulation of cardiac muscle hypertrophy negative regulation of endothelial cell migration positive regulation of transcription, DNA-templated ventricular cardiac muscle tissue morphogenesis multicellular organism development development of the heart positive regulation of gene expression cell adhesion negative regulation of cell migration positive regulation of cardiac muscle cell proliferation positive regulation of cartilage development negative regulation of cell growth regulation of cardiac muscle hypertrophy in response to stress atrial cardiac muscle tissue morphogenesis regulation of cardiac muscle contraction sarcomere organization ventricular cardiac muscle cell development activin receptor signaling pathway BMP signaling pathway regulation of signaling receptor activity cell development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27302 12154 Ensembl ENSG00000163217 ENSMUSG00000030046 UniProt O95393 Q9R229 RefSeq (mRNA) NM_014482 NM_009756 RefSeq (protein) NP_055297 NP_033886 Location (UCSC) Chr 2: 68.86 – 68.87 Mb Chr 6: 87.41 – 87.41 Mb PubMed search
Wikidata
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Bone morphogenetic protein 10 (BMP10) is a protein that in humans is encoded by the BMP10 gene.

BMP10 is a polypeptide belonging to the TGF-β superfamily of proteins. It is a novel protein that, unlike most other BMP's, is likely to be involved in the trabeculation of the heart. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP10 is categorized as a BMP since it shares a large sequence homology with other BMP's in the TGF-β superfamily.

BMP10 has also emerged as a novel atrial specific biomarker used in cardiovascular research, especially in the field of atrial fibrillation (AF). Latest research has revealed strong associations between plasma concentration of BMP10 and the risk for ischemic stroke in patients with atrial fibrillation as well as with the risk of AF recurrence after ablation for AF.

Further reading

• Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, et al. (April 2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes and Immunity. 11 (3): 232–238. doi:10.1038/gene.2010.1. PMID 20237496. S2CID 11183658.
• Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, et al. (April 2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–731. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
• Mazerbourg S, Sangkuhl K, Luo CW, Sudo S, Klein C, Hsueh AJ (September 2005). "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses". The Journal of Biological Chemistry. 280 (37): 32122–32132. doi:10.1074/jbc.M504629200. PMID 16049014.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (October 2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Research. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nakano N, Hori H, Abe M, Shibata H, Arimura T, Sasaoka T, et al. (December 2007). "Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy". American Journal of Physiology. Heart and Circulatory Physiology. 293 (6) H3396–403. doi:10.1152/ajpheart.00311.2007. PMID 17921333. S2CID 45084505.
• Marroni F, Pfeufer A, Aulchenko YS, Franklin CS, Isaacs A, Pichler I, et al. (August 2009). "A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project". Circulation. Cardiovascular Genetics. 2 (4): 322–328. doi:10.1161/CIRCGENETICS.108.833806. PMC 2760953. PMID 20031603.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• David L, Mallet C, Mazerbourg S, Feige JJ, Bailly S (March 2007). "Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells". Blood. 109 (5): 1953–1961. doi:10.1182/blood-2006-07-034124. PMID 17068149.

External links

• Human BMP10 genome location and BMP10 gene details page in the UCSC Genome Browser.