BAMBI

This article is about the human gene. For the German media award, see Bambi Award. For other uses, see BAMBI (disambiguation).

BAMBI
Identifiers
Aliases	BAMBI, NMA, BMP and activin membrane-bound inhibitor, BMP and activin membrane bound inhibitor
External IDs	OMIM: 604444; MGI: 1915260; GeneCards: BAMBI
Gene location (Human) Chr. Chromosome 10 (human) Band 10p12.1 Start 28,677,510 bp End 28,682,932 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 A1 Start 3,507,923 bp End 3,516,404 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia periodontal fiber left ovary cardiac muscle tissue of right atrium right auricle of heart cartilage tissue right ovary glomerulus adrenal cortex left adrenal gland Top expressed in tooth molar endocardial cushion Meckel's cartilage bones of pectoral girdle clavicle hair follicle upper lip atrioventricular valve body of femur More reference expression data BioGPS n/a
Gene ontology Molecular function type II transforming growth factor beta receptor binding frizzled binding Cellular component cytoplasm integral component of membrane plasma membrane membrane Biological process positive regulation of transcription, DNA-templated positive regulation of protein binding negative regulation of transforming growth factor beta receptor signaling pathway cell migration positive regulation of epithelial to mesenchymal transition positive regulation of cell population proliferation regulation of cell shape positive regulation of canonical Wnt signaling pathway transforming growth factor beta receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 25805 68010 Ensembl ENSG00000095739 ENSMUSG00000024232 UniProt Q13145 Q9D0L6 RefSeq (mRNA) NM_012342 NM_026505 RefSeq (protein) NP_036474 NP_080781 Location (UCSC) Chr 10: 28.68 – 28.68 Mb Chr 18: 3.51 – 3.52 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

BMP and activin membrane-bound inhibitor homolog, also known as BAMBI, is a protein which in humans is encoded by the BAMBI gene.

Function

This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF beta) family. The encoded protein is a pseudoreceptor that lacks an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta. Therefore, this has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Lin Z, Gao C, Ning Y, et al. (2008). "The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling". J. Biol. Chem. 283 (48): 33053–8. doi:10.1074/jbc.M804039200. PMC 2662247. PMID 18838381.
• Sekiya T, Oda T, Matsuura K, Akiyama T (2004). "Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling". Biochem. Biophys. Res. Commun. 320 (3): 680–4. doi:10.1016/j.bbrc.2004.06.017. PMID 15240101.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fritzmann J, Morkel M, Besser D, et al. (2009). "A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential". Gastroenterology. 137 (1): 165–75. doi:10.1053/j.gastro.2009.03.041. PMID 19328798.
• Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
• Khin SS, Kitazawa R, Win N, et al. (2009). "BAMBI gene is epigenetically silenced in subset of high-grade bladder cancer". Int. J. Cancer. 125 (2): 328–38. doi:10.1002/ijc.24318. PMID 19326429. S2CID 32084443.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204. PMID 12107411.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sekiya T, Adachi S, Kohu K, et al. (2004). "Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells". J. Biol. Chem. 279 (8): 6840–6. doi:10.1074/jbc.M310876200. PMID 14660579.
• Togo N, Ohwada S, Sakurai S, et al. (2008). "Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer". World J. Gastroenterol. 14 (31): 4880–8. doi:10.3748/wjg.14.4880. PMC 2739940. PMID 18756595.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
• Zhang Z, Henzel WJ (2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Degen WG, Weterman MA, van Groningen JJ, et al. (1996). "Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts". Int. J. Cancer. 65 (4): 460–5. doi:10.1002/(SICI)1097-0215(19960208)65:4<460::AID-IJC12>3.0.CO;2-E. PMID 8621228.

External links

• BAMBI+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human BAMBI genome location and BAMBI gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.