Agathobacter rectalis
| Agathobacter rectalis | |
|---|---|
Scientific classification  | |
| Domain: | Bacteria |
| Kingdom: | Bacillati |
| Phylum: | Bacillota |
| Class: | Clostridia |
| Order: | Eubacteriales |
| Family: | Lachnospiraceae |
| Genus: | Agathobacter |
| Species: | A. rectalis |
| Binomial name | |
| Agathobacter rectalis Rosero et al. 2016[1] | |
| Type strain | |
| ATCC 33656[2] | |
| Synonyms | |
|
Bacteroides rectalis,[2] | |
Agathobacter rectalis is a gram-positive, butyrate-producing, anaerobic, rod-shaped and non-spore-forming bacterium from the genus of Agathobacter with a single flagellate which occur in the rumen content of sheep and cows[1][2] and in the gut microbiome of humans.[3] It is suggested that Eubacterium rectale is a synonym of A. rectalis,[1] but this is not universally accepted.[4][5]
A 2021 study looked at the gut microbiome from 5,700 samples from humans around the world of various ages.[3] 50 species were found in over 70% of the participants, and of those A. rectalis was the most abundant species.[3] The study noted that A. rectalis has a large diversity in sequence identity which may be a factor in why the studies found this to be the most abundant.[3]
In patients with Alzheimer's disease there can be a reduced abundance of short chain fatty acid producing bacteria, including A. rectalis.[3] Reduced numbers of A. rectalis in the gut may be a risk factor for Alzheimer's disease.[6]
A. rectalis was found to be depleted in the gut microbiome of people with metabolic dysfunction-associated steatotic liver disease (MASLD) and can be used as an indicator of MASLD severity.[7]
References
[edit]- 1 2 3 Rosero, J. A.; Killer, J.; Sechovcová, H.; Mrázek, J.; Benada, O.; Fliegerová, K.; Havlík, J.; Kopečný, J. (2016). "Reclassification of Eubacterium rectale (Hauduroy et al. 1937) Prévot 1938 in a new genus Agathobacter gen. nov. as Agathobacter rectalis comb. nov., and description of Agathobacter ruminis sp. nov., isolated from the rumen contents of sheep and cows". International Journal of Systematic and Evolutionary Microbiology. 66 (2): 768–773. doi:10.1099/ijsem.0.000788. hdl:11104/0259127. PMID 26619944.
- 1 2 3 4 5 6
"[Eubacterium] rectale". www.uniprot.org. - 1 2 3 4 5 Hiseni, Pranvera; Rudi, Knut; Wilson, Robert C.; Hegge, Finn Terje; Snipen, Lars (2021-07-31). "HumGut: a comprehensive human gut prokaryotic genomes collection filtered by metagenome data". Microbiome. 9 (1): 165. doi:10.1186/s40168-021-01114-w. ISSN 2049-2618. PMC 8325300. PMID 34330336.
- ↑ Sheridan, P. O.; Duncan, S. H.; Walker, A. W.; Scott, K. P.; Louis, P.; Flint, H. J. (2016). "Objections to the proposed reclassification of Eubacterium rectale as Agathobacter rectalis". International Journal of Systematic and Evolutionary Microbiology. 66 (5): 2106. doi:10.1099/ijsem.0.000969. PMID 26916277.
- ↑ Zuo, G.; Hao, B. (2016). "Whole-genome-based phylogeny supports the objections against the reclassification of Eubacterium rectale to Agathobacter rectalis". International Journal of Systematic and Evolutionary Microbiology. 66 (6): 2451. doi:10.1099/ijsem.0.001047. PMID 27032096.
- ↑ Lv, Xinhuang; Zhan, Lu; Ye, Tao; Xie, Huijia; Chen, Zhibo; Lin, Yan; Cai, Xianlei; Yang, Wenwen; Liao, Xiaolan; Liu, Jiaming; Sun, Jing (2024). "Gut commensal Agathobacter rectalis alleviates microglia-mediated neuroinflammation against pathogenesis of Alzheimer disease". iScience. 27 (11) 111116. Bibcode:2024iSci...27k1116L. doi:10.1016/j.isci.2024.111116. PMC 11532950. PMID 39498309.
- ↑ Medina-Méndez, Juan Manuel; Iruzubieta, Paula; Fernández-López, Raúl; Crespo, Javier; de la Cruz, Fernando (2025-12-18). "Bacterial metabolic signatures in MASLD predicted through gene-centric studies in stool metagenomes". BMC Microbiology. 26 (1): 70. doi:10.1186/s12866-025-04549-5. ISSN 1471-2180. PMC 12853991. PMID 41413769.
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