// Workers AI · dad joke modeWhat did ATF7IP say to its date? "You're a binding match

ATF7IP
Identifiers
Aliases	ATF7IP, AM, ATF-IP, MCAF, MCAF1, p621, activating transcription factor 7 interacting protein
External IDs	OMIM: 613644; MGI: 1858965; GeneCards: ATF7IP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RPQ
Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.1 Start 14,365,632 bp End 14,502,935 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 G1 Start 136,506,167 bp End 136,610,862 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell cardia nipple tendon of biceps brachii renal medulla visceral pleura pylorus ventral tegmental area superior surface of tongue trigeminal ganglion Top expressed in zygote genital tubercle tail of embryo trigeminal ganglion interventricular septum lymph node mesenteric lymph nodes lobe of cerebellum cerebellar vermis secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATPase activity protein binding transcription corepressor activity Cellular component nucleus transcription regulator complex nucleoplasm cytosol nuclear body Biological process positive regulation of transcription, DNA-templated DNA methylation regulation of RNA polymerase II transcription preinitiation complex assembly viral process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated regulation of protein stability protein stabilization positive regulation of DNA methylation-dependent heterochromatin assembly Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 55729 54343 Ensembl ENSG00000171681 ENSMUSG00000030213 UniProt Q6VMQ6 Q7TT18 RefSeq (mRNA) NM_001286514 NM_001286515 NM_018179 NM_181352 NM_019426 RefSeq (protein) NP_001273443 NP_001273444 NP_060649 NP_851997 NP_060649.3 NP_062299 NP_001375123 NP_001375124 NP_001375125 NP_001375126 Location (UCSC) Chr 12: 14.37 – 14.5 Mb Chr 6: 136.51 – 136.61 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Activating transcription factor 7-interacting protein 1 is a protein that in humans is encoded by the ATF7IP gene.

Interactions

ATF7IP has been shown to interact with MBD1. In mice with T cell-specific deletion of Atf7ip, the protein has been shown to play a role in regulating T helper 17 cell (Th17) differentiation due to increased IL-2 production upon stimulation of the T cell receptor (TCR). This TCR stimulation occurs through deposition of H3K9me3, a repressive histone mark.

Further reading

• Yamada K, Kawata H, Shou Z, Hirano S, Mizutani T, Yazawa T, et al. (July 2003). "Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3". The Biochemical Journal. 373 (Pt 1): 167–178. doi:10.1042/BJ20021866. PMC 1223464. PMID 12659632.
• Morris JA, Kandpal G, Ma L, Austin CP (2004). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Human Molecular Genetics. 12 (13): 1591–1608. doi:10.1093/hmg/ddg162. PMID 12812986.
• Wang H, An W, Cao R, Xia L, Erdjument-Bromage H, Chatton B, et al. (August 2003). "mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression". Molecular Cell. 12 (2): 475–487. doi:10.1016/j.molcel.2003.08.007. PMID 14536086.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, et al. (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–1332. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Ichimura T, Watanabe S, Sakamoto Y, Aoto T, Fujita N, Nakao M (April 2005). "Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins". The Journal of Biological Chemistry. 280 (14): 13928–13935. doi:10.1074/jbc.M413654200. PMID 15691849.
• Chang LK, Chung JY, Hong YR, Ichimura T, Nakao M, Liu ST (2005). "Activation of Sp1-mediated transcription by Rta of Epstein-Barr virus via an interaction with MCAF1". Nucleic Acids Research. 33 (20): 6528–6539. doi:10.1093/nar/gki956. PMC 1298921. PMID 16314315.
• Uchimura Y, Ichimura T, Uwada J, Tachibana T, Sugahara S, Nakao M, et al. (August 2006). "Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation". The Journal of Biological Chemistry. 281 (32): 23180–23190. doi:10.1074/jbc.M602280200. PMID 16757475.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, et al. (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

• Human ATF7IP genome location and ATF7IP gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Activating transcription factor 7-interacting protein 1 (ATF7IP)