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ARHGAP33
Identifiers
Aliases	ARHGAP33, NOMA-GAP, SNX26, TCGAP, Rho GTPase activating protein 33
External IDs	OMIM: 614902; MGI: 2673998; GeneCards: ARHGAP33
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.12 Start 35,774,532 bp End 35,788,822 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 B1 Start 30,522,226 bp End 30,535,060 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone right uterine tube right hemisphere of cerebellum right frontal lobe C1 segment anterior pituitary right testis left testis right ovary Top expressed in superior frontal gyrus olfactory tubercle piriform cortex visual cortex primary visual cortex subiculum nucleus accumbens ganglionic eminence ventricular zone prefrontal cortex More reference expression data BioGPS n/a
Gene ontology Molecular function phosphatidylinositol binding protein binding GTPase activator activity protein kinase binding Cellular component cytosol cytoplasm plasma membrane cell cortex actin cytoskeleton protein-containing complex dendritic spine Biological process regulation of small GTPase mediated signal transduction protein transport positive regulation of GTPase activity signal transduction small GTPase mediated signal transduction response to toxic substance regulation of dendritic spine morphogenesis Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 115703 233071 Ensembl ENSG00000004777 ENSMUSG00000036882 UniProt O14559 Q80YF9 RefSeq (mRNA) NM_001172630 NM_052948 NM_001366178 NM_001289670 NM_001289682 NM_178252 RefSeq (protein) NP_001166101 NP_443180 NP_001353107 NP_001276599 NP_001276611 NP_839983 Location (UCSC) Chr 19: 35.77 – 35.79 Mb Chr 7: 30.52 – 30.54 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Rho GTPase-activating protein 33 is a protein that in humans is encoded by the ARHGAP33 gene (previously SNX26). Predictions suggest that it may be involved in insulin signaling and glucose transport, potentially as a downstream effector of RHOQ.

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The specific function of this protein has not been elucidated. Alternative splice variants have been described but their full length nature has not been determined.

Further reading

• Xu Y, Seet LF, Hanson B, Hong W (2002). "The Phox homology (PX) domain, a new player in phosphoinositide signalling". Biochem. J. 360 (Pt 3): 513–30. doi:10.1042/0264-6021:3600513. PMC 1222253. PMID 11736640.
• Dehal P, Predki P, Olsen AS, et al. (2001). "Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution". Science. 293 (5527): 104–11. doi:10.1126/science.1060310. PMID 11441184. S2CID 826987.
• Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chiang SH, Hwang J, Legendre M, et al. (2003). "TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport". EMBO J. 22 (11): 2679–91. doi:10.1093/emboj/cdg262. PMC 156759. PMID 12773384.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19" (PDF). Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Liu H, Nakazawa T, Tezuka T, Yamamoto T (2006). "Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP". J. Biol. Chem. 281 (33): 23611–9. doi:10.1074/jbc.M511205200. PMID 16777849.