ARB2A

ARB2A
Identifiers
Aliases	ARB2A, C5orf21, family with sequence similarity 172 member A, Toupee, FAM172A, ARB2 cotranscriptional regulator A
External IDs	MGI: 1915925; GeneCards: ARB2A
Gene location (Human)
Chr.	Chromosome 5 (human)
End	94,111,699 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	78,314,354 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; tendon of biceps brachii; ; caput epididymis; ; optic nerve; ; epithelium of colon; ; corpus epididymis; ; paraflocculus of cerebellum; ; tail of epididymis; ; bronchial epithelial cell; ; stromal cell of endometrium;
	Top expressed in
	spermatocyte; ; zygote; ; medial ganglionic eminence; ; Region I of hippocampus proper; ; superior cervical ganglion; ; ventricular zone; ; secondary oocyte; ; genital tubercle; ; thymus; ; hand;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	siRNA binding;
Cellular component	endoplasmic reticulum; extracellular region; nucleus; cytoplasm;
Biological process	regulation of alternative mRNA splicing, via spliceosome; neural crest cell development; mRNA processing; RNA splicing; heterochromatin assembly by small RNA;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	83989
	68675
	ENSG00000113391
	ENSMUSG00000064138
	Q8WUF8
	Q3TNH5
	NM_001163417; NM_001163418; NM_032042
	NM_001163419; NM_001163420; NM_138312
	NP_001156889; NP_001156890; NP_114431
	NP_001156891; NP_001156892; NP_612185
	Wikidata
View/Edit Human	View/Edit Mouse

Cotranscriptional regulator ARB2A is a protein that in humans is encoded by the ARB2A gene (previously FAM172A).^[5]^[6] ARB2A has been predicted to be involved in regulating alternative RNA splicing through interaction with AGO2 and CHD7.^[7] ARB2A has a paralog, ARB2BP, which may be a non-functional pseudogene.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000113391 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000064138 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
↑ "ARB2A ARB2 cotranscriptional regulator A [ Homo sapiens (human) ]". 2026-08-05. Retrieved 2026-08-17.
↑ "Q8WUF8 · ARB2A_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-17.
↑ "A6NC97 · ARB2P_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-17.

External links

Human ARB2A genome location and ARB2A gene details page in the UCSC Genome Browser.

Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000113391 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000064138 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11230166-5] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[entrez-6] "ARB2A ARB2 cotranscriptional regulator A [ Homo sapiens (human) ]". 2026-08-05. Retrieved 2026-08-17.

[uniprot-7] "Q8WUF8 · ARB2A_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-17.

[8] "A6NC97 · ARB2P_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-17.

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ARB2A

References

External links

Further reading