APIP

APIP
Identifiers
Aliases	APIP, APIP2, CGI29, MMRP19, hCGI-29, APAF1 interacting protein
External IDs	OMIM: 612491; MGI: 1926788; HomoloGene: 6277; GeneCards: APIP; OMA:APIP - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4M6R
Enzyme activity
Gene location (Human)
Chr.	Chromosome 11 (human)
End	34,916,379 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	102,922,989 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; muscle of thigh; ; right adrenal gland; ; corpus callosum; ; right adrenal cortex; ; monocyte; ; skeletal muscle tissue; ; left adrenal gland; ; left adrenal cortex; ; gastrocnemius muscle;
	Top expressed in
	right ventricle; ; interventricular septum; ; zygote; ; cardiac muscle tissue of left ventricle; ; muscle of thigh; ; secondary oocyte; ; right kidney; ; digastric muscle; ; temporal muscle; ; brown adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; lyase activity; identical protein binding; methylthioribulose 1-phosphate dehydratase activity; zinc ion binding;
Cellular component	cytoplasm; cytosol;
Biological process	methionine biosynthetic process; negative regulation of apoptotic process; cellular amino acid biosynthetic process; regulation of ERK1 and ERK2 cascade; apoptotic process; pyroptosis; protein homotetramerization; L-methionine salvage from methylthioadenosine; L-methionine salvage from S-adenosylmethionine;
	Sources:Amigo / QuickGO
Orthologs
	51074
	56369
	ENSG00000149089
	ENSMUSG00000010911
	Q96GX9
	Q9WVQ5
	NM_015957
	NM_019735; NM_001355473; NM_001355474
	NP_057041
	NP_062709; NP_001342402; NP_001342403
	Wikidata
View/Edit Human	View/Edit Mouse

APAF1-interacting protein is a protein that in humans is encoded by the APIP gene.^[5]^[6]^[7] It is an enzyme with Methylthioribulose 1-phosphate dehydratase activity^[8]^[9] which is involved in the methionine salvage pathway.

APIP deficiency is associated with cell death^[10] and cancer.

Interactions

APIP has been shown to interact with APAF1.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000149089 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000010911 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
1 2 Cho DH, Hong YM, Lee HJ, Woo HN, Pyo JO, Mak TW, Jung YK (Sep 2004). "Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein". J Biol Chem. 279 (38): 39942–50. doi:10.1074/jbc.M405747200. PMID 15262985.
↑ "Entrez Gene: APIP APAF1 interacting protein".
↑ Mary C, Duek P, Salleron L, Tienz P, Bumann D, Bairoch A, Lane L (2012). Di Cunto F (ed.). "Functional Identification of APIP as Human mtnB, a Key Enzyme in the Methionine Salvage Pathway". PLOS ONE. 7 (12) e52877. Bibcode:2012PLoSO...752877M. doi:10.1371/journal.pone.0052877. PMC 3532061. PMID 23285211.
↑ Kang W, Hong SH, Lee HM, Kim NY, Lim YC, Le Le TM, Lim B, Kim HC, Kim TY, Ashida H, Yokota A, Hah SS, Chun KH, Jung YK, Yang JK (2014). "Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme". Proceedings of the National Academy of Sciences. 111 (1): E54-61. Bibcode:2014PNAS..111E..54K. doi:10.1073/pnas.1308768111. PMC 3890807. PMID 24367089.
↑ Ko DC, Gamazon ER, Shukla KP, Pfuetzner RA, Whittington D, Holden TD, Brittnacher MJ, Fong C, Radey M, Ogohara C, Stark AL, Akey JM, Dolan ME, Wurfel MM, Miller SI (2012). "Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death". Proceedings of the National Academy of Sciences. 109 (35): E2343–E2352. doi:10.1073/pnas.1206701109. PMC 3435171. PMID 22837397.

External links

Human APIP genome location and APIP gene details page in the UCSC Genome Browser.

Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000149089 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000010911 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10810093-5] Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.

[pmid15262985-6] 1 2 Cho DH, Hong YM, Lee HJ, Woo HN, Pyo JO, Mak TW, Jung YK (Sep 2004). "Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein". J Biol Chem. 279 (38): 39942–50. doi:10.1074/jbc.M405747200. PMID 15262985.

[entrez-7] "Entrez Gene: APIP APAF1 interacting protein".

[8] Mary C, Duek P, Salleron L, Tienz P, Bumann D, Bairoch A, Lane L (2012). Di Cunto F (ed.). "Functional Identification of APIP as Human mtnB, a Key Enzyme in the Methionine Salvage Pathway". PLOS ONE. 7 (12) e52877. Bibcode:2012PLoSO...752877M. doi:10.1371/journal.pone.0052877. PMC 3532061. PMID 23285211.

[structure-9] Kang W, Hong SH, Lee HM, Kim NY, Lim YC, Le Le TM, Lim B, Kim HC, Kim TY, Ashida H, Yokota A, Hah SS, Chun KH, Jung YK, Yang JK (2014). "Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme". Proceedings of the National Academy of Sciences. 111 (1): E54-61. Bibcode:2014PNAS..111E..54K. doi:10.1073/pnas.1308768111. PMC 3890807. PMID 24367089.

[10] Ko DC, Gamazon ER, Shukla KP, Pfuetzner RA, Whittington D, Holden TD, Brittnacher MJ, Fong C, Radey M, Ogohara C, Stark AL, Akey JM, Dolan ME, Wurfel MM, Miller SI (2012). "Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death". Proceedings of the National Academy of Sciences. 109 (35): E2343–E2352. doi:10.1073/pnas.1206701109. PMC 3435171. PMID 22837397.

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APIP

Interactions

References

External links

Further reading