ANP32E

ANP32E
Identifiers
Aliases	ANP32E, LANP-L, LANPL, acidic nuclear phosphoprotein 32 family member E
External IDs	OMIM: 609611; MGI: 1913721; GeneCards: ANP32E
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4CAY, 4NFT
Gene location (Human)
Chr.	Chromosome 1 (human)
End	150,236,156 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	95,854,702 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; caput epididymis; ; corpus epididymis; ; dorsal motor nucleus of vagus nerve; ; ventricular zone; ; epithelium of nasopharynx; ; retinal pigment epithelium; ; tail of epididymis; ; Epithelium of choroid plexus; ; gingival epithelium;
	Top expressed in
	tail of embryo; ; neural layer of retina; ; genital tubercle; ; otic vesicle; ; pineal gland; ; otic placode; ; cumulus cell; ; saccule; ; ventricular zone; ; abdominal wall;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	histone binding; phosphatase inhibitor activity;
Cellular component	cytoplasm; nucleus; Swr1 complex; cytoplasmic vesicle;
Biological process	negative regulation of catalytic activity; histone exchange; nucleosome assembly; nucleocytoplasmic transport; regulation of apoptotic process; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	81611
	66471
	ENSG00000143401
	ENSMUSG00000015749
	Q9BTT0
	P97822
	NM_001136478; NM_001136479; NM_001280559; NM_001280560; NM_030920
	NM_001253757; NM_001253758; NM_023210
	NP_001129950; NP_001129951; NP_001267488; NP_001267489; NP_112182
	NP_001240686; NP_001240687; NP_075699
	Wikidata
View/Edit Human	View/Edit Mouse

Acidic leucine-rich nuclear phosphoprotein 32 family member E is a protein that in humans is encoded by the ANP32E gene.^[5]^[6] The ANP32E gene is located on chromosome 1q22.^[5]

Function

In mammalian cells, ANP32E has been shown to be an H2A.Z chaperone capable of promoting the removal of H2A.Z from chromatin.^[7] In brain tissue, ANP32E together with Cpd1 regulate protein phosphatase 2A activity at synapses during synaptogenesis^[8] and has been observed to form a complex with ANP32A and SET that stabilizes short-lived mRNAs containing AU-rich elements, as well as having acetyltransferase inhibitory activity (in a complex with SET) and having a role in chromatin remodeling and transcriptional regulation.^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000143401 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015749 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Jiang M, Ma Y, Ni X, Cao G, Ji C, Cheng H, et al. (November 2002). "Molecular cloning and characterization of a novel human gene (ANP32E alias LANPL) from human fetal brain". Cytogenetic and Genome Research. 97 (1–2): 68–71. doi:10.1159/000064058. PMID 12438741. S2CID 30549428.
↑ "Entrez Gene: ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E". Archived from the original on August 20, 2023.
↑ Obri A, Ouararhni K, Papin C, Diebold ML, Padmanabhan K, Marek M, et al. (2014). "ANP32E is a histone chaperone that removes H2A.Z from chromatin". Nature. 505 (7485): 648–653. Bibcode:2014Natur.505..648O. doi:10.1038/nature12922. PMID 24463511. S2CID 4406370.
↑ Costanzo RV, Vilá-Ortíz GJ, Perandones C, Carminatti H, Matilla A, Radrizzani M (2006). "Anp32e/Cpd1 regulates protein phosphatase 2A activity at synapses during synaptogenesis". The European Journal of Neuroscience. 23 (2): 309–324. doi:10.1111/j.1460-9568.2005.04555.x. PMID 16420440. S2CID 46587416.
↑ Santa-Coloma TA (2003). "Anp32e (Cpd1) and related protein phosphatase 2 inhibitors". Cerebellum. 2 (4). London, England: 310–320. doi:10.1080/14734220310017212. PMID 14964690. S2CID 21454532.

External links

Human ANP32E genome location and ANP32E gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000143401 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015749 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Jiang_2002-5] 1 2 Jiang M, Ma Y, Ni X, Cao G, Ji C, Cheng H, et al. (November 2002). "Molecular cloning and characterization of a novel human gene (ANP32E alias LANPL) from human fetal brain". Cytogenetic and Genome Research. 97 (1–2): 68–71. doi:10.1159/000064058. PMID 12438741. S2CID 30549428.

[entrez-6] "Entrez Gene: ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E". Archived from the original on August 20, 2023.

[Obri_2014-7] Obri A, Ouararhni K, Papin C, Diebold ML, Padmanabhan K, Marek M, et al. (2014). "ANP32E is a histone chaperone that removes H2A.Z from chromatin". Nature. 505 (7485): 648–653. Bibcode:2014Natur.505..648O. doi:10.1038/nature12922. PMID 24463511. S2CID 4406370.

[Costanzo_2006-8] Costanzo RV, Vilá-Ortíz GJ, Perandones C, Carminatti H, Matilla A, Radrizzani M (2006). "Anp32e/Cpd1 regulates protein phosphatase 2A activity at synapses during synaptogenesis". The European Journal of Neuroscience. 23 (2): 309–324. doi:10.1111/j.1460-9568.2005.04555.x. PMID 16420440. S2CID 46587416.

[Santa-Coloma_2003-9] Santa-Coloma TA (2003). "Anp32e (Cpd1) and related protein phosphatase 2 inhibitors". Cerebellum. 2 (4). London, England: 310–320. doi:10.1080/14734220310017212. PMID 14964690. S2CID 21454532.

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ANP32E

Function

See also

References

Further reading

External links