// Workers AI · dad joke modeWhat did ALDH3B2 say? "I'm dehydrogenating to meet you

ALDH3B2
Identifiers
Aliases	ALDH3B2, ALDH8, aldehyde dehydrogenase 3 family member B2
External IDs	OMIM: 601917; MGI: 1920708; GeneCards: ALDH3B2; OMA:ALDH3B2 - orthologs
Enzyme activity
Gene location (Human)
Chr.	Chromosome 11 (human)
End	67,681,224 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	4,022,103 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; skin of arm; ; vulva; ; skin of abdomen; ; gingival epithelium; ; oral cavity; ; parotid gland; ; human penis; ; nipple; ; skin of hip;
	Top expressed in
	granulocyte; ; lumbar subsegment of spinal cord; ; proximal tubule; ; right kidney; ; outer nuclear layer; ; skin of back; ; skin of external ear; ; lip; ; morula; ; blastocyst;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	3-chloroallyl aldehyde dehydrogenase activity; oxidoreductase activity; aldehyde dehydrogenase [NAD(P)+ activity]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;
Cellular component	lipid droplet;
Biological process	ethanol catabolic process; metabolism; alcohol metabolic process; lipid metabolism; sphingolipid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	222
	73458
	ENSG00000132746
	ENSMUSG00000037263
	P48448
	J3QMK6
NM_000695; NM_001031615; NM_001354345; NM_001393400; NM_001393401;
	NM_001393402
	NM_028545
	NP_000686; NP_001026786; NP_001341274
	NP_082821
	Wikidata
View/Edit Human	View/Edit Mouse

Aldehyde dehydrogenase family 3 member B2 is an enzyme that, in humans, is encoded by the ALDH3B2 gene.^[5]^[6]^[7]

This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene for this particular family member is over 10 kb in length. The expression of these transcripts is restricted to the salivary gland among the human tissues examined. Alternate transcriptional splice variants have been characterized.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000132746 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037263 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hsu LC, Chang WC (Dec 1996). "Sequencing and expression of the human ALDH8 encoding a new member of the aldehyde dehydrogenase family". Gene. 174 (2): 319–22. doi:10.1016/0378-1119(96)00087-X. PMID 8890755.
↑ Hsu LC, Chang WC, Yoshida A (Jun 1997). "Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison". Gene. 189 (1): 89–94. doi:10.1016/S0378-1119(96)00839-6. PMID 9161417.
1 2 "Entrez Gene: ALDH3B2 aldehyde dehydrogenase 3 family, member B2".

External links

Human ALDH3B2 genome location and ALDH3B2 gene details page in the UCSC Genome Browser.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Hsu LC, Chang WC, Lin SW, Yoshida A (1995). "Cloning and Characterization of Genes Encoding Four Additional Human Aldehyde Dehydrogenase Isozymes". Enzymology and Molecular Biology of Carbonyl Metabolism 5. Advances in Experimental Medicine and Biology. Vol. 372. pp. 159–68. doi:10.1007/978-1-4615-1965-2_21. ISBN 978-1-4613-5808-4. PMID 7484374.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000132746 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037263 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8890755-5] Hsu LC, Chang WC (Dec 1996). "Sequencing and expression of the human ALDH8 encoding a new member of the aldehyde dehydrogenase family". Gene. 174 (2): 319–22. doi:10.1016/0378-1119(96)00087-X. PMID 8890755.

[pmid9161417-6] Hsu LC, Chang WC, Yoshida A (Jun 1997). "Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison". Gene. 189 (1): 89–94. doi:10.1016/S0378-1119(96)00839-6. PMID 9161417.

[entrez-7] 1 2 "Entrez Gene: ALDH3B2 aldehyde dehydrogenase 3 family, member B2".

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v t e Aldehyde dehydrogenases (EC 1.2.1)
Family 1	Retinaldehyde — ALDH1A1 ALDH1A2 ALDH1A3 Acetaldehyde — ALDH1B1 Formyltetrahydrofolate — ALDH1L1 ALDH1L2
Family 2	ALDH2
Family 3	Dimeric NADP-preferring — (ALDH3A1) Fatty aldehyde — (ALDH3A2) ALDH3B1 ALDH3B2
Other	ALDH4A1 ALDH5A1 ALDH6A1 α-Aminoadipic semialdehyde — (ALDH7A1) ALDH8A1 ALDH9A1 ALDH16A1 ALDH18A1 Glyceraldehyde 3-phosphate — (GAPDH)

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// Workers AI · dad joke modeWhat did ALDH3B2 say? "I'm dehydrogenating to meet you

References

External links

Further reading