AKAP5

AKAP5
Identifiers
Aliases	AKAP5, AKAP75, AKAP79, H21, A-kinase anchoring protein 5
External IDs	OMIM: 604688; MGI: 2685104; HomoloGene: 15854; GeneCards: AKAP5; OMA:AKAP5 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2H9R, 3LL8
Gene location (Human) Chr. Chromosome 14 (human) Band 14q23.3 Start 64,465,499 bp End 64,474,503 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 C3 Start 76,371,665 bp End 76,380,927 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 entorhinal cortex superior frontal gyrus postcentral gyrus nucleus accumbens primary visual cortex endothelial cell caudate nucleus prefrontal cortex Top expressed in left lung lobe olfactory tubercle nucleus accumbens right lung right lung lobe lateral septal nucleus globus pallidus temporal lobe Region I of hippocampus proper amygdala More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase A binding calmodulin binding protein binding protein kinase A regulatory subunit binding adenylate cyclase binding SH3 domain binding protein phosphatase 2B binding beta-2 adrenergic receptor binding molecular adaptor activity glutamate receptor binding GABA receptor binding scaffold protein binding Cellular component cytosol membrane plasma membrane cytoplasmic side of plasma membrane postsynaptic density dendrite membrane dendritic spine membrane raft excitatory synapse intracellular anatomical structure Biological process protein targeting signal transduction positive regulation of protein kinase A signaling chemical synaptic transmission adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway negative regulation of adenylate cyclase activity regulation of protein kinase A signaling positive regulation of adenylate cyclase activity positive regulation of protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9495 238276 Ensembl ENSG00000179841 ENSMUSG00000021057 UniProt P24588 Q6PG46 D3YVF0 RefSeq (mRNA) NM_004857 NM_001101471 RefSeq (protein) NP_004848 NP_004848.3 NP_001094941 Location (UCSC) Chr 14: 64.47 – 64.47 Mb Chr 12: 76.37 – 76.38 Mb PubMed search
Wikidata
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A-kinase anchor protein 5 is a protein that in humans is encoded by the AKAP5 gene.

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene is intronless and encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin 2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.

Interactions

AKAP5 has been shown to interact with:

• Calcineurin and
• GABRB3.

External links

• Human AKAP5 genome location and AKAP5 gene details page in the UCSC Genome Browser.

Further reading

• Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res. 52: 409–29, discussion 429–30. PMID 9238861.
• Michel JJ, Scott JD (2002). "AKAP mediated signal transduction". Annu. Rev. Pharmacol. Toxicol. 42: 235–57. doi:10.1146/annurev.pharmtox.42.083101.135801. PMID 11807172.
• Hirsch AH, Glantz SB, Li Y, et al. (1992). "Cloning and expression of an intron-less gene for AKAP 75, an anchor protein for the regulatory subunit of cAMP-dependent protein kinase II beta". J. Biol. Chem. 267 (4): 2131–4. doi:10.1016/S0021-9258(18)45852-8. PMID 1733921.
• Carr DW, Stofko-Hahn RE, Fraser ID, et al. (1991). "Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif". J. Biol. Chem. 266 (22): 14188–92. doi:10.1016/S0021-9258(18)98665-5. PMID 1860836.
• Coghlan VM, Perrino BA, Howard M, et al. (1995). "Association of protein kinase A and protein phosphatase 2B with a common anchoring protein". Science. 267 (5194): 108–11. Bibcode:1995Sci...267..108C. doi:10.1126/science.7528941. PMID 7528941.
• Glantz SB, Li Y, Rubin CS (1993). "Characterization of distinct tethering and intracellular targeting domains in AKAP75, a protein that links cAMP-dependent protein kinase II beta to the cytoskeleton". J. Biol. Chem. 268 (17): 12796–804. doi:10.1016/S0021-9258(18)31458-3. PMID 8509414.
• Faux MC, Scott JD (1997). "Regulation of the AKAP79-protein kinase C interaction by Ca2+/Calmodulin". J. Biol. Chem. 272 (27): 17038–44. doi:10.1074/jbc.272.27.17038. PMID 9202019.
• Kashishian A, Howard M, Loh C, et al. (1998). "AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region". J. Biol. Chem. 273 (42): 27412–9. doi:10.1074/jbc.273.42.27412. PMID 9765270.
• Paolillo M, Feliciello A, Porcellini A, et al. (1999). "The type and the localization of cAMP-dependent protein kinase regulate transmission of cAMP signals to the nucleus in cortical and cerebellar granule cells". J. Biol. Chem. 274 (10): 6546–52. doi:10.1074/jbc.274.10.6546. PMID 10037748.
• Dodge KL, Carr DW, Sanborn BM (1999). "Protein kinase A anchoring to the myometrial plasma membrane is required for cyclic adenosine 3',5'-monophosphate regulation of phosphatidylinositide turnover". Endocrinology. 140 (11): 5165–70. doi:10.1210/endo.140.11.7133. PMID 10537145.
• Fraser ID, Cong M, Kim J, et al. (2000). "Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling". Curr. Biol. 10 (7): 409–12. doi:10.1016/S0960-9822(00)00419-X. PMID 10753752.
• Sík A, Gulácsi A, Lai Y, et al. (2000). "Localization of the A kinase anchoring protein AKAP79 in the human hippocampus". Eur. J. Neurosci. 12 (4): 1155–64. doi:10.1046/j.1460-9568.2000.00002.x. PMID 10762347. S2CID 40933732.
• Colledge M, Dean RA, Scott GK, et al. (2000). "Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex". Neuron. 27 (1): 107–19. doi:10.1016/S0896-6273(00)00013-1. PMID 10939335.
• Indolfi C, Stabile E, Coppola C, et al. (2001). "Membrane-bound protein kinase A inhibits smooth muscle cell proliferation in vitro and in vivo by amplifying cAMP-protein kinase A signals". Circ. Res. 88 (3): 319–24. doi:10.1161/01.res.88.3.319. PMID 11179200.
• Dart C, Leyland ML (2001). "Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1". J. Biol. Chem. 276 (23): 20499–505. doi:10.1074/jbc.M101425200. PMID 11287423.
• Xie G, Raufman JP (2001). "Association of protein kinase A with AKAP150 facilitates pepsinogen secretion from gastric chief cells". Am. J. Physiol. Gastrointest. Liver Physiol. 281 (4): G1051–8. doi:10.1152/ajpgi.2001.281.4.G1051. PMID 11557526. S2CID 20939022.