AK3L1
Adenylate kinase isoenzyme 4, mitochondrial is an enzyme that in humans is encoded by the AK4 gene.[5][6]
This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1.[6] Expression of AK4 may regulate global cellular ATP levels and modulate the AMPK signaling pathway.[7]
References
[edit]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000162433 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028527 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Noma T, Fujisawa K, Yamashiro Y, Shinohara M, Nakazawa A, Gondo T, et al. (August 2001). "Structure and expression of human mitochondrial adenylate kinase targeted to the mitochondrial matrix". The Biochemical Journal. 358 (Pt 1): 225–232. doi:10.1042/0264-6021:3580225. PMC 1222051. PMID 11485571.
- 1 2 "Entrez Gene: AK3L1 adenylate kinase 3-like 1".
- ↑ Lanning NJ, Looyenga BD, Kauffman AL, Niemi NM, Sudderth J, DeBerardinis RJ, et al. (May 2014). "A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels". Cell Reports. 7 (3): 907–917. doi:10.1016/j.celrep.2014.03.065. PMC 4046887. PMID 24767988.
Further reading
[edit]- Povey S, Slaughter CA, Wilson DE, Gormley IP, Buckton KE, Perry P, et al. (May 1976). "Evidence for the assignment of the loci AK1, AK3 and ACONs to chromosome 9 in man". Annals of Human Genetics. 39 (4): 413–422. doi:10.1111/j.1469-1809.1976.tb00145.x. PMID 182062. S2CID 40660799.
- Xu G, O'Connell P, Stevens J, White R (1992). "Characterization of human adenylate kinase 3 (AK3) cDNA and mapping of the AK3 pseudogene to an intron of the NF1 gene". Genomics. 13 (3): 537–542. doi:10.1016/0888-7543(92)90122-9. PMID 1639383.
- Robson EB, Meera Khan P (1983). "Report of the committee on the genetic constitution of chromosomes 7, 8, and 9. Oslo Conference (1981): Sixth International Workshop on Human Gene Mapping". Cytogenetics and Cell Genetics. 32 (1–4): 144–152. doi:10.1159/000131694. PMID 7140357.
- Nobumoto M, Yamada M, Song S, Inouye S, Nakazawa A (January 1998). "Mechanism of mitochondrial import of adenylate kinase isozymes". Journal of Biochemistry. 123 (1): 128–135. doi:10.1093/oxfordjournals.jbchem.a021899. PMID 9504419.
- Yoneda T, Sato M, Maeda M, Takagi H (1999). "Identification of a novel adenylate kinase system in the brain: cloning of the fourth adenylate kinase". Brain Research. Molecular Brain Research. 62 (2): 187–195. doi:10.1016/S0169-328X(98)00249-6. PMID 9813319.
- Noma T, Adachi N, Nakazawa A (1999). "Cloning and functional characterization of the promoter region of the gene encoding human adenylate kinase isozyme 3". Biochemical and Biophysical Research Communications. 264 (3): 990–997. doi:10.1006/bbrc.1999.1616. PMID 10544043.
External links
[edit]- Human AK3 genome location and AK3 gene details page in the UCSC Genome Browser.
- Human AK4 genome location and AK4 gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: P27144 (Adenylate kinase 4, mitochondrial) at the PDBe-KB.
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