AGPAT5

AGPAT5
Identifiers
Aliases	AGPAT5, 1LPAATE, 1-acylglycerol-3-phosphate O-acyltransferase 5
External IDs	OMIM: 614796; MGI: 1196345; HomoloGene: 10153; GeneCards: AGPAT5; OMA:AGPAT5 - orthologs
Enzyme activity
Gene location (Human)
Chr.	Chromosome 8 (human)
End	6,761,503 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	18,941,377 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; ventricular zone; ; ganglionic eminence; ; left testis; ; right testis; ; endometrium; ; C1 segment; ; Achilles tendon; ; caudate nucleus; ; islet of Langerhans;
	Top expressed in
	triceps brachii muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; digastric muscle; ; skin of external ear; ; seminal vesicula; ; endothelial cell of lymphatic vessel; ; pineal gland; ; umbilical cord; ; decidua;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein binding; acyltransferase activity; 1-acylglycerol-3-phosphate O-acyltransferase activity;
Cellular component	integral component of membrane; nuclear envelope; membrane; endoplasmic reticulum membrane; mitochondrial outer membrane; mitochondrion; endoplasmic reticulum; nucleus;
Biological process	phosphatidic acid biosynthetic process; CDP-diacylglycerol biosynthetic process; lipid metabolism; hematopoietic progenitor cell differentiation; phospholipid biosynthetic process; metabolism; acylglycerol metabolic process; phospholipid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	55326
	52123
	ENSG00000155189; ENSG00000284980
	ENSMUSG00000031467
	Q9NUQ2
	Q9D1E8
	NM_018361
	NM_026792
	NP_060831
	NP_081068
	Wikidata
View/Edit Human	View/Edit Mouse

1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon is an enzyme that is encoded by the AGPAT5 gene in humans.^[5]

This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis.^[5]

References

1 2 3 ENSG00000284980 GRCh38: Ensembl release 89: ENSG00000155189, ENSG00000284980 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031467 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)".

External links

Human AGPAT5 genome location and AGPAT5 gene details page in the UCSC Genome Browser.

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lu B, Jiang YJ, Zhou Y, et al. (2005). "Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart". Biochem. J. 385 (Pt 2): 469–77. doi:10.1042/BJ20041348. PMC 1134718. PMID 15367102.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Agarwal AK, Barnes RI, Garg A (2006). "Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity". Arch. Biochem. Biophys. 449 (1–2): 64–76. doi:10.1016/j.abb.2006.03.014. PMID 16620771.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 ENSG00000284980 GRCh38: Ensembl release 89: ENSG00000155189, ENSG00000284980 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031467 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)".

[1]

[2]

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[5]

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AGPAT5

References

External links

Further reading